Baseline resolution of isomers by traveling wave ion mobility mass spectrometry: investigating the eff ects of polarizable drift gases and ionic charge distribution (page i)
Priscila M. Lalli, Yuri E. Corilo, Maíra Fasciotti, Maria Francesca Riccio, Gilberto Fernandes de Sá, Romeu J. Daroda, Gustavo H. M. F. Souza, Michael McCullagh, Michael D. Bartberger, Marcos N. Eberlin and Iain Campuzano
Article first published online: 16 SEP 2013 | DOI: 10.1002/jms.3192
Coupling ion mobility (IM) with MS offers a potential solution for resolving structural isomers. Ion mobility separates ions according to size and shape because they interact differently with the neutral drift-gas molecules. However, the majority of routine IM-MS measurements rely on drift-gases with low polarizability such as He and N2. In the Special Feature Lalli et al. investigate polarizable molecules as drift-gas to determine if the dipolar ion-neutral interactions enhance ion mobility separations of shape-similar analytes. Their results suggest that the polarizability of the drift-gas and the distribution of charge on the ion influence the degree of IM separation.