Journal of Mass Spectrometry

Cover image for Vol. 49 Issue 8

August 2014

Volume 49, Issue 8

Pages 674–765

  1. Cover picture

    1. Top of page
    2. Cover picture
    3. Cover story
    4. Special feature: perspective
    5. Research articles
    6. Application notes
    7. JMS letters
    1. Cover picture (page i)

      Article first published online: 14 JUL 2014 | DOI: 10.1002/jms.3390

      Thumbnail image of graphical abstract
  2. Cover story

    1. Top of page
    2. Cover picture
    3. Cover story
    4. Special feature: perspective
    5. Research articles
    6. Application notes
    7. JMS letters
    1. A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry (page ii)

      M. L. Manier, J. M. Spraggins, M. L. Reyzer, J. L. Norris and R. M. Caprioli

      Article first published online: 14 JUL 2014 | DOI: 10.1002/jms.3273

      Thumbnail image of graphical abstract

      Imaging Mass Spectrometry is increasingly being applied to the study of small endogenous compounds, including metabolites, neurotransmitters, lipids and other compounds as well. However, due to the high degree of structural homology and the lack of true “blank” samples, generation of images of unequivocal molecular identity is challenging. In this special feature perspective article, Richard Caprioli and colleagues at Vanderbilt University Medical Center discuss these challenges and describe an analytical strategy that combines a number of advanced instrumental methods to identify and confirm the accurate spatial localization of select amino acids and amine-containing metabolites. By combining derivatization, MSn, and accurate mass, followed by confirmation via HPLC-MS, they are able to demonstrate the localization of several endogenous metabolites in biological tissue specimens.

  3. Special feature: perspective

    1. Top of page
    2. Cover picture
    3. Cover story
    4. Special feature: perspective
    5. Research articles
    6. Application notes
    7. JMS letters
  4. Research articles

    1. Top of page
    2. Cover picture
    3. Cover story
    4. Special feature: perspective
    5. Research articles
    6. Application notes
    7. JMS letters
  5. Application notes

    1. Top of page
    2. Cover picture
    3. Cover story
    4. Special feature: perspective
    5. Research articles
    6. Application notes
    7. JMS letters
    1. Hydrazide and hydrazine reagents as reactive matrices for MALDI-MS to detect gaseous aldehydes (pages 742–749)

      Yasushi Shigeri, Shinya Ikeda, Akikazu Yasuda, Masanori Ando, Hiroaki Sato and Tomoya Kinumi

      Article first published online: 8 JUL 2014 | DOI: 10.1002/jms.3408

  6. JMS letters

    1. Top of page
    2. Cover picture
    3. Cover story
    4. Special feature: perspective
    5. Research articles
    6. Application notes
    7. JMS letters
    1. Ion internal energy, salt tolerance and a new technical improvement of desorption nanoelectrospray (pages 750–754)

      Lucie Hartmanová, Petr Fryčák, Miroslav Soural, František Tureček, Vladimír Havlíček and Karel Lemr

      Article first published online: 8 JUL 2014 | DOI: 10.1002/jms.3383

    2. Characterization of a μ-oxo-bridged diiron porphyrin by ESI-LTQ-Orbitrap-MS (pages 763–765)

      André M. N. Silva, António Aguiar, Salete S. Balula, Ana M. G. Silva and Maria Rangel

      Article first published online: 8 JUL 2014 | DOI: 10.1002/jms.3405

SEARCH

SEARCH BY CITATION