HBeAg and anti-hbe detection by radioimmunoassay: Correlation with vertical transmission of hepatitis B virus in Taiwan

Authors

  • Dr. Cladd E. Stevens,

    Corresponding author
    1. Laboratories of Epidemiology and Virology, The Lindsley F. Kimball Research Institute of The New York Blood Center, New York, New York
    • Address reprint requests to Dr. Cladd E. Stevens, Laboratory of Epidemiology, The New York Blood Center, 310 East 67th Street, New York, New York 10021, USA
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  • Robert A. Neurath,

    1. Laboratories of Epidemiology and Virology, The Lindsley F. Kimball Research Institute of The New York Blood Center, New York, New York
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  • R. Palmer Beasley,

    1. Epidemiology and Clinical Investigation Department, U.S. Naval Medical Research Unit No.2, Taipei, Taiwan, Republic of China, Department of Epidemiology and International Health, University of Washington, Seattle, Washington
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  • Wolf Szmuness

    1. Laboratories of Epidemiology and Virology, The Lindsley F. Kimball Research Institute of The New York Blood Center, New York, New York
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Abstract

A sensitive radioimmunoassay technique was used to detect hepatitis B e antigen (HBeAg). A strong correlation was found between HBeAg positivity of the serum of hepatitis B surface antigen (HBsAg) carrier women in Taiwan and the subsequent development of surface antigenemia in their babies. All babies who became chronic HBsAg carriers were born to HbeAg positive women, maternal HBeAg positivity being a better prior indication of chronic antigenemia developing in the baby than the HBsAg titer in the mother's serum.

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