Immunogenicity of influenza A/USSR (H1N1) subunit vaccine in unprimed young adults
Article first published online: 6 DEC 2005
Copyright © 1981 Wiley-Liss, Inc., A Wiley Company
Journal of Medical Virology
Volume 7, Issue 2, pages 135–142, 1981
How to Cite
Frank, A. L., Paul Glezen, W., Cate, T. R. and Webster, R. G. (1981), Immunogenicity of influenza A/USSR (H1N1) subunit vaccine in unprimed young adults. J. Med. Virol., 7: 135–142. doi: 10.1002/jmv.1890070207
- Issue published online: 6 DEC 2005
- Article first published online: 6 DEC 2005
- Manuscript Accepted: 11 MAR 1981
- US Public Health Service contracts AI42528, AI92611, and AI42510 from the National Institute of Allergy and Infectious Disease.
- influenza A/USSR (H1N1);
- subunit vaccine;
Purified subunit vaccines (HANAflu) containing 20 /xg of hemagglutinin of influenza A/USSR/90/77 (H1N1) alone or with 1–5% whole virus were compared to commercially available vaccines for reactogenicity and immunogenicity in unprimed young adults. Reactions to all vaccines were minimal. Sera from volunteers who received two intramuscular doses of vaccine or placebo were tested by hemagglutination-inhibition and neutralization tests. HANAflu with 1 m̈g (5%) whole virus added was not different in immunogenicity from commercial vaccine. Both commercial vaccine and HANAflu with 1 m̈g whole virus added gave higher seroconversion rates and more neutralization titers ≥ 4 log2 than HANAflu alone and HANAflu + 0.2 m̈g (1%) whole virus. Thus, the HANAflu subunit vaccine alone was less immunogenic than commercial vaccine in unprimed persons. However, addition of 1 m̈g (5%) whole virus, but not 0.2 m̈g (1%), eliminated this difference. There may be a role for addition of small amounts of whole virus to subunit influenza vaccines to overcome lower immunogenicity in unprimed populations.