Radioimmunoassay detection of igm antibodies to the hbv-associated delta (δ) antigen: Clinical significance in δ infection
Article first published online: 6 DEC 2005
Copyright © 1982 Wiley-Liss, Inc., A Wiley Company
Journal of Medical Virology
Volume 9, Issue 2, pages 131–138, 1982
How to Cite
Smedile, A., Lavarini, C., Crivelli, O., Raimondo, G., Fassone, M. and Rizzetto, M. (1982), Radioimmunoassay detection of igm antibodies to the hbv-associated delta (δ) antigen: Clinical significance in δ infection. J. Med. Virol., 9: 131–138. doi: 10.1002/jmv.1890090208
- Issue published online: 6 DEC 2005
- Article first published online: 6 DEC 2005
- Manuscript Accepted: 13 JUL 1981
- HBV-associated δ agent;
- IgM antibody RIA;
- HBV infection;
- HBsAg carriers
A sensitive radioimmunoassay was developed for specific detection of IgM antibodies to the hepatitis B virus-associated δ antigen. The test is based on the selective absorption of IgM by anti–IgM fixed on a solid phase.
Transient primary IgM anti4 responses with no conversion to a secondary IgG response were observed in acute self–limited δ infection. IgM anti-δ was invariably found in hepatitis B surface antigen (HBsAg) carriers with active δ infection and liver disease, while it was absent in HBsAg-positive or negative individuals with anti-δ of IgG class but without liver damage or intrahepatic δ antigen.
IgM anti-δ appears useful in defining the epidemiology of acute δ infection and in the serological diagnosis of active δ disease from nonpathogenic or past δ infection.