Age- and sex-related study of hepatitis B virus chronic carrier state in infants from an endemic area (Senegal)
Article first published online: 7 DEC 2005
Copyright © 1987 Wiley Subscription Service, Inc., A Wiley Company
Journal of Medical Virology
Volume 22, Issue 1, pages 1–5, May 1987
How to Cite
Coursaget, P., Yvonnet, B., Chotard, J., Vincelot, P., Sarr, M., Diouf, C., Chiron, J. P. and Diop-Mar, I. (1987), Age- and sex-related study of hepatitis B virus chronic carrier state in infants from an endemic area (Senegal). J. Med. Virol., 22: 1–5. doi: 10.1002/jmv.1890220102
- Issue published online: 7 DEC 2005
- Article first published online: 7 DEC 2005
- Manuscript Accepted: 15 SEP 1986
- Ministère de la Coopération (France)
- The Secrétariat d'Etat á la Recherche Scientifique et Technique (Sénégal)
- The Commission of the European Communities
This report concerns hepatitis B virus (HBV) infections observed in 155 infants from Senegal. studied with a view to determining the factors involved in development of the chronic carrier state. A chronic carrier state was observed in 50.3% of the infants.
This study confirms that the risk of chronic carriage is linked to age. This risk declines very rapidly with age, falling from 82% in infants under 6 months old, to 15% in children between the ages of 2 and 3 years. Spontaneous elimination of hepatitis B surface antigen (HBsAg) is uncommon in HBsAg carriers during childhood.
The difference observed in chronic carriage between males and females is due to a difference in susceptibility of the two sexes to the development of the chronic carrier state: HBV infections (before 2 years of age) lead to a chronic carriage in 77% of males as against 50% of females.
These conclusions are important in view of the immunisation programs being carried out against hepatitis B virus in endemic areas. For a maximum efficacy, vaccination must be carried out at birth, or shortly afterwards.