Article

New genotype of hepatitis C virus in South Africa

  1. T. Ohno1,
  2. M. Mizokami1,
  3. C. J. Tibbs2,
  4. K. Ohba1,
  5. K. Suzuki1,
  6. R.-R. Wu1,
  7. K. T. Nouri-Aria2,
  8. Dr. Roger Williams2,*

Article first published online: 7 DEC 2005

DOI: 10.1002/jmv.1890420414

Issue

Journal of Medical Virology

Journal of Medical Virology

Volume 42, Issue 4, pages 409–413, April 1994

Additional Information

How to Cite

Ohno, T., Mizokami, M., Tibbs, C. J., Ohba, K., Suzuki, K., Wu, R.-R., Nouri-Aria, K. T. and Williams, R. (1994), New genotype of hepatitis C virus in South Africa. J. Med. Virol., 42: 409–413. doi: 10.1002/jmv.1890420414

Author Information

  1. 1

    Second Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

  2. 2

    Institute of Liver Studies, King's College Hospital, Denmark Hill, London, England

*C.B.E., Institute of Liver Studies, King's College Hospital, London SE5 9RS, England

Publication History

  1. Issue published online: 7 DEC 2005
  2. Article first published online: 7 DEC 2005
  3. Manuscript Accepted: 28 JUL 1993

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (453K)

Keywords:

  • core region;
  • partial nucleotide sequences;
  • polymerase chain reaction

Abstract

Partial nucleotide sequences in the core region of the hepatitis C viral genome were determined by reverse transcription followed by polymerase chain reaction, in a patient with chronic hepatitis from South Africa. These nucleotide sequences showed a low degree of homology with known types of HCV: the degree of homology between the nucleotide sequences of these clones with HC-J1, J4, J6, J7, Tr, and Eb-1 were 86.1-87.3%, 87.3-87.9%, 83.0-83.9%, 81.1-82.0%, 81.0-82.2%, and 82.8-83.4%, respectively, and that the deduced amino acid sequence homologies between these clones and HC-J1, J4, H6, J7, Tr, and Eb-1 were 90.7-91.6%, 89.7-91.6%, 91.6-93.5%, 90.7-91.6%, 81.5-82.4%, and 89.2-90.2%, respectively. The nucleotide sequence homologies of these clones with HC-J1, J4, J6, J7, Tr, and Eb-1 were very low, compared to those between the same genotype. Further comparison using molecular evolutionary methods suggested that this sequence should be classified in a new genotype. © 1994 Wiley-Liss, inc.

Get PDF (453K)