Research Article

Retrospective, longitudinal analysis of serum human herpesvirus-8 viral DNA load in AIDS-related kaposi's sarcoma patients before and after diagnosis

  1. Abeltje M. Polstra1,
  2. Marion Cornelissen1,
  3. Jaap Goudsmit2,3,
  4. Antoinette C. van der Kuyl1,*

Article first published online: 14 SEP 2004

DOI: 10.1002/jmv.20192

Issue

Journal of Medical Virology

Journal of Medical Virology

Volume 74, Issue 3, pages 390–396, November 2004

Additional Information

How to Cite

Polstra, A. M., Cornelissen, M., Goudsmit, J. and van der Kuyl, A. C. (2004), Retrospective, longitudinal analysis of serum human herpesvirus-8 viral DNA load in AIDS-related kaposi's sarcoma patients before and after diagnosis. Journal of Medical Virology, 74: 390–396. doi: 10.1002/jmv.20192

Author Information

  1. 1

    Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands

  2. 2

    Centre for Poverty-Related Communicable Diseases, Academic Medical Centre, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands

  3. 3

    Crucell Holland B.V., Leiden, The Netherlands

*Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.

Publication History

  1. Issue published online: 14 SEP 2004
  2. Article first published online: 14 SEP 2004
  3. Manuscript Accepted: 5 JUL 2004

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Keywords:

  • HHV-8;
  • real-time PCR;
  • cohort;
  • AIDS

Abstract

Human herpesvirus 8 (HHV-8) is detected more often in patients progressing towards Kaposi's sarcoma (KS) than in patients who do not develop the disease, suggesting that the level of viremia might be associated with Kaposi's sarcoma disease and progression. Longitudinal serum samples from 19 AIDS-Kaposi's sarcoma patients, ranging from 2 years before KS till 2 years after KS diagnosis were tested. No correlation was found between viral load and progression to KS, or disease stage. J. Med. Virol. 74:390–396, 2004. © 2004 Wiley-Liss, Inc.

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