Detection of herpesvirus-6A in a case of subacute cerebellitis and myoclonic dystonia

  1. Elisa Borghi2,
  2. Elisabetta Pagani1,
  3. Roberta Mancuso1,
  4. Serena Delbue1,
  5. Marilena Valli1,
  6. Romina Mazziotti1,
  7. Lucio Giordano3,
  8. Roberto Micheli3,
  9. Pasquale Ferrante1,2,*

Article first published online: 12 JAN 2005

DOI: 10.1002/jmv.20285

Issue

Journal of Medical Virology

Journal of Medical Virology

Volume 75, Issue 3, pages 427–429, March 2005

Additional Information

How to Cite

Borghi, E., Pagani, E., Mancuso, R., Delbue, S., Valli, M., Mazziotti, R., Giordano, L., Micheli, R. and Ferrante, P. (2005), Detection of herpesvirus-6A in a case of subacute cerebellitis and myoclonic dystonia. Journal of Medical Virology, 75: 427–429. doi: 10.1002/jmv.20285

Author Information

  1. 1

    Laboratory of Biology, Don C. Gnocchi Foundation ONLUS, IRCCS, Milan, Italy

  2. 2

    Chair of Virology, Department of Biomedical Science and Technology, University of Milan, Milan, Italy

  3. 3

    Department of Child Neurology, Spedali Civili, Brescia, Italy

*Laboratory of Biology, Don C. Gnocchi Foundation, IRCCS, via Capecelatro, 66, I-20148, Milan, Italy.

Publication History

  1. Issue published online: 12 JAN 2005
  2. Article first published online: 12 JAN 2005
  3. Manuscript Accepted: 2 NOV 2004

Funded by

  • Italian Ministry of Health

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Keywords:

  • human herpesvirus 6;
  • truncal ataxia;
  • myoclonic dystonia;
  • HHV-6A and B variants

Abstract

This is a case study of a child who developed roseola infantum first, then varicella, and was later affected by acute cerebellar syndrome, severe truncal ataxia, and myoclonic dystonia. Human herpesvirus 6 (HHV-6) A and B were detected in the cerebrospinal fluid (CSF) and peripheral blood, respectively, upon ataxia onset. The intricacy of this case suggests multifaceted conclusions ranging from the need for a multidirectional approach to neurological diseases, to confirmation of a more pronounced neurotropism of HHV-6A and a possible role of viruses in myoclonic dystonia syndrome, although this last hypothesis should be confirmed by larger studies. J. Med. Virol. 75:427–429, 2005. © 2005 Wiley-Liss, Inc.

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