A preliminary report of this work was presented at the 10th International Symposium on Viral Hepatitis and Liver Disease held April 9–13, 2000 in Atlanta, Georgia.
Genetic heterogeneity of hepatitis E virus*
Article first published online: 14 AUG 2001
Copyright © 2001 Wiley-Liss, Inc.
Journal of Medical Virology
Volume 65, Issue 2, pages 282–292, October 2001
How to Cite
Schlauder, G. G. and Mushahwar, I. K. (2001), Genetic heterogeneity of hepatitis E virus. J. Med. Virol., 65: 282–292. doi: 10.1002/jmv.2031
- Issue published online: 14 AUG 2001
- Article first published online: 14 AUG 2001
- Manuscript Accepted: 9 NOV 2000
- non A–C hepatitis;
- sequence comparisons;
- phylogenetic analysis
Hepatitis E virus (HEV) infection has been considered a disease associated with developing regions and attributed to oral-fecal transmission due to inadequate sanitation. Several recent findings, however, have led to a new understanding of this virus. A number of novel isolates have been identified in patients with acute hepatitis from regions not considered endemic for HEV, and these individuals reported no recent travel to HEV endemic areas. In addition, a number of HEV-like sequences have also been isolated from swine worldwide, suggesting the potential of an animal reservoir. Although full-length sequence is available for some strains, the majority of HEV isolates have only been sequenced partially. Sequence comparisons and phylogenetic analyses were performed to determine the genotypic distribution of HEV isolates, based on the partial sequence data available. It has been suggested that HEV isolates segregate into four major genotypes based on full-length comparisons. These analyses, however, indicate that HEV may be distributed into at least nine different groups. J. Med. Virol. 65:282–292, 2001. © 2001 Wiley-Liss, Inc.