Establishment of functional B cell memory against parvovirus B19 capsid proteins may be associated with resolution of persistent infection
Article first published online: 18 NOV 2005
Copyright © 2005 Wiley-Liss, Inc.
Journal of Medical Virology
Volume 78, Issue 1, pages 125–128, January 2006
How to Cite
Corcoran, A., Crowley, B., Dewhurst, C., Pizer, B.L. and Doyle, S. (2006), Establishment of functional B cell memory against parvovirus B19 capsid proteins may be associated with resolution of persistent infection. J. Med. Virol., 78: 125–128. doi: 10.1002/jmv.20513
- Issue published online: 18 NOV 2005
- Article first published online: 18 NOV 2005
- Manuscript Accepted: 30 SEP 2005
- Commission of the European Communities. Grant Number: QLK2-CT-2001-00877
- B cell ELISpot;
Parvovirus B19 (B19) infection can occur during acute lymphoblastic leukemia and persistent viral infection can occur despite intravenous immunoglobulin administration. Here, evidence is presented that resolution of persistent B19 infection in an acute lymphoblastic leukemia patient may be associated with the simultaneous strengthening of antigen-specific B cell memory against the B19 capsid protein VP2 and diminution in the memory response against the B19 non-structural protein 1 (NS1). Determination of antigen-specific B cell memory status may enhance the serological and molecular analyses of persistent B19 infection. J. Med. Virol. 78:125–128, 2006. © 2005 Wiley-Liss, inc.