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Establishment of functional B cell memory against parvovirus B19 capsid proteins may be associated with resolution of persistent infection

  1. A. Corcoran1,†,
  2. B. Crowley2,
  3. C. Dewhurst3,
  4. B.L. Pizer3,
  5. S. Doyle1,*

Article first published online: 18 NOV 2005

DOI: 10.1002/jmv.20513

Issue

Journal of Medical Virology

Journal of Medical Virology

Volume 78, Issue 1, pages 125–128, January 2006

Additional Information

How to Cite

Corcoran, A., Crowley, B., Dewhurst, C., Pizer, B.L. and Doyle, S. (2006), Establishment of functional B cell memory against parvovirus B19 capsid proteins may be associated with resolution of persistent infection. J. Med. Virol., 78: 125–128. doi: 10.1002/jmv.20513

Author Information

  1. 1

    Department of Biology and National Institute for Cellular Biotechnology, National University of Ireland, Maynooth, Co. Kildare, Ireland

  2. 2

    Department of Clinical Microbiology, St. James Hospital, Dublin, Ireland, and National Virus Reference Laboratory, University College, Dublin, Ireland

  3. 3

    Department of Pediatric Oncology, Royal Liverpool Children's Hospital-Alder Hey, Liverpool, UK

  1. †

    Biotrin, 93, The Rise, Mount Merrion, Co. Dublin, Ireland.

*Department of Biology and National Institute for Cellular Biotechnology, National University of Ireland, Maynooth, Co. Kildare, Ireland.

Publication History

  1. Issue published online: 18 NOV 2005
  2. Article first published online: 18 NOV 2005
  3. Manuscript Accepted: 30 SEP 2005

Funded by

  • Commission of the European Communities. Grant Number: QLK2-CT-2001-00877

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Keywords:

  • ALL;
  • immunocompromised;
  • B cell ELISpot;
  • leukemia;
  • erythrovirus

Abstract

Parvovirus B19 (B19) infection can occur during acute lymphoblastic leukemia and persistent viral infection can occur despite intravenous immunoglobulin administration. Here, evidence is presented that resolution of persistent B19 infection in an acute lymphoblastic leukemia patient may be associated with the simultaneous strengthening of antigen-specific B cell memory against the B19 capsid protein VP2 and diminution in the memory response against the B19 non-structural protein 1 (NS1). Determination of antigen-specific B cell memory status may enhance the serological and molecular analyses of persistent B19 infection. J. Med. Virol. 78:125–128, 2006. © 2005 Wiley-Liss, inc.

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