Hepatitis B virus concentrations in serum determined by sensitive quantitative assays in patients with established chronic hepatitis delta virus infection
Article first published online: 8 OCT 2001
Copyright © 2001 Wiley-Liss, Inc.
Journal of Medical Virology
Volume 65, Issue 3, pages 478–484, 1 November 2001
How to Cite
Sakugawa, H., Nakasone, H., Nakayoshi, T., Kawakami, Y., Yamashiro, T., Maeshiro, T., Kinjo, F., Saito, A. and Zukeran, H. (2001), Hepatitis B virus concentrations in serum determined by sensitive quantitative assays in patients with established chronic hepatitis delta virus infection. J. Med. Virol., 65: 478–484. doi: 10.1002/jmv.2061
- Issue published online: 8 OCT 2001
- Article first published online: 8 OCT 2001
- Manuscript Accepted: 28 MAR 2001
- Japan Society for the Promotion of Science
- hepatitis delta virus;
- HBV DNA;
- HDV RNA;
To clarify the correlation between hepatitis B virus (HBV) DNA levels and serum alanine aminotransferase (ALT) levels in patients with established chronic hepatitis delta virus (HDV) infection, sensitive HBV quantitative assays were used for the study. Thirty-four consecutive patients with chronic liver disease who were positive for both hepatitis B surface antigen (HBsAg) and antibody to HDV (anti-HDV), including 19 patients with chronic hepatitis, 8 patients with liver cirrhosis and 7 patients with hepatocellular carcinoma. All were negative for hepatitis Be antigen (HBeAg) and positive for antibody to HBeAg. HBV DNA was detected in 25 (73.5%) of the 34 patients using real-time detection PCR, and the HBV DNA levels of these patients were significantly lower compared with HBeAg status and ALT level-matched patients with chronic liver disease positive for HBsAg but negative for anti-HDV. There was no correlation between serum HBV DNA and ALT levels among the 34 patients with chronic liver disease positive for anti-HDV. Whereas serum ALT levels in anti-HDV-positive HBsAg carriers with HDV RNA were significantly higher than those without HDV RNA. Liver damage in patients with established chronic HDV infection may be caused mainly by ongoing HDV infection not by HBV replication. J. Med. Virol. 65:478–484, 2001. © 2001 Wiley-Liss, Inc.