High-risk human papillomavirus infection of the genital tract of women with a previous history or current high-grade vulvar intraepithelial neoplasia

Authors

  • Frederic Goffin,

    1. Départements d'Obstétrique et Gynécologie, Pathologie et Microbiologie-Infectiologie, Hôpital Notre Dame-Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada
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  • Marie-Hélène Mayrand,

    1. Départements d'Obstétrique et Gynécologie, Pathologie et Microbiologie-Infectiologie, Hôpital Notre Dame-Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada
    2. Division of Cancer Epidemiology, McGill University, Montreal, Quebec, Canada
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  • Philippe Gauthier,

    1. Départements d'Obstétrique et Gynécologie, Pathologie et Microbiologie-Infectiologie, Hôpital Notre Dame-Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada
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  • A. Alobaid,

    1. Départements d'Obstétrique et Gynécologie, Pathologie et Microbiologie-Infectiologie, Hôpital Notre Dame-Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada
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  • Christian Lussier,

    1. Départements d'Obstétrique et Gynécologie, Pathologie et Microbiologie-Infectiologie, Hôpital Notre Dame-Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada
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  • Diane Provencher,

    1. Départements d'Obstétrique et Gynécologie, Pathologie et Microbiologie-Infectiologie, Hôpital Notre Dame-Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada
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  • Pierre Drouin,

    1. Départements d'Obstétrique et Gynécologie, Pathologie et Microbiologie-Infectiologie, Hôpital Notre Dame-Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada
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  • Eduardo L. Franco,

    1. Division of Cancer Epidemiology, McGill University, Montreal, Quebec, Canada
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  • François Coutlée

    Corresponding author
    1. Départements d'Obstétrique et Gynécologie, Pathologie et Microbiologie-Infectiologie, Hôpital Notre Dame-Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada
    2. Division of Cancer Epidemiology, McGill University, Montreal, Quebec, Canada
    3. Laboratoire de Virologie Moléculaire, Centre de Recherche, Hôpital Notre-Dame du CHUM, Québec, Canada
    • Département de Microbiologie et Infectiologie, Hôpital Notre-Dame du Centre Hospitalier de l'Université de Montréal, 1560 Sherbrooke est, Montréal (Québec), H2L 4M1, Canada.
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Abstract

Human papillomavirus (HPV) infection is associated with high-grade vulvar intraepithelial neoplasia (VIN-3). The prevalence of anogenital HPV infection in women with previously treated VIN-3 has not been documented yet. This cross-sectional study compared high-risk HPV DNA detection rates in women with past (n = 30) and current (n = 22) VIN-3 to those without current or past VIN (n = 86). HPV DNA was detected in vulvar and cervical samples with Hybrid Capture 2 (HC-2). Smoking was associated in multivariate analysis with current VIN-3 (odds ratio (OR) 8.3, 95% confidence interval (CI) 2.0–8.2) and any VIN-3 history (OR 6.5, 95% CI 2.5–16.5). High-risk HPV DNA was found on the vulva of 64%, 33%, and 20% of women with current VIN-3, past VIN-3, and without previous or current VIN, respectively. After controlling for age and smoking, high-risk HPV vulvar infection was associated with cervical high-risk HPV infection (OR 8.6, 95% CI 2.8–26.5; P = 0.001). After controlling for age, HPV infection was more often multifocal in women with current VIN-3 compared to women with previous but no current VIN-3 lesion (OR 17.6, 95% CI 1.4–227.2). Multifocal vulvar HPV infection was detected in women with previous or active VIN-3. Longitudinal studies are required to determine if the multifocality of HPV infection on the vulva could explain the high recurrence rate of VIN-3. J. Med. Virol. 78:814–819, 2006. © 2006 Wiley-Liss, Inc.

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