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Keywords:

  • herpes simplex virus type 1;
  • human trigeminal ganglia;
  • human optic nerves;
  • polymerase chain reaction

Abstract

Herpes simplex virus type 1 (HSV-1) DNA was extracted from human trigeminal ganglia of 121 cadavers aged between 3 months and 94 years, and its PCR amplification was performed for the RL2 HSV-1 sequence using two pairs of primers. The HSV-1 DNA was detected in 74 of 121 patients (61%); 70/74 bilaterally, 3/74 only on the left side, and 1/74 only on the right side. Although the PCR-positive rate was significantly higher in advanced age, the correlation between the PCR-positive rate and gender was unclear. Additionally, HSV-1 DNA was not detected in any of the 50 optic nerve samples. J. Med. Virol. 78:1584–1587, 2006. © 2006 Wiley-Liss, Inc.