The effect of early virological response in health-related quality of life in HCV-infected patients

Authors

  • Lucas C. Quarantini,

    Corresponding author
    1. Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil
    2. Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Universidade Federal de São Paulo, São Paulo, Brazil
    • Professor Edgard Santos University Hospital, Federal University of Bahia, Brazil, Rua Doutor Augusto Viana, s/n Canela, Salvador-Bahia, 40 110-909 Brazil.
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  • Ângela Miranda-Scippa,

    1. Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil
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  • Susana Batista-Neves,

    1. Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil
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  • Amanda Galvão-de-Almeida,

    1. Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil
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  • Acioly L. Lacerda,

    1. Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Universidade Federal de São Paulo, São Paulo, Brazil
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  • Taís S. Moriyama,

    1. Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Universidade Federal de São Paulo, São Paulo, Brazil
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  • Aline S. Sampaio,

    1. Programa para estudo dos transtornos do espectro obsessivo-compulsivo (PROTOC), Departamento & Instituto de Psiquiatria da Faculdade de Medicina da Universidade Sao Paulo, Sao Paulo, Brazil
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  • Ana C. Melcop,

    1. Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Universidade Federal de São Paulo, São Paulo, Brazil
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  • Maria I. Schinoni,

    1. Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil
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  • Irismar R. de Oliveira,

    1. Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil
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  • Raymundo Paraná,

    1. Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil
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  • Rodrigo A. Bressan

    1. Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Universidade Federal de São Paulo, São Paulo, Brazil
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Abstract

Twenty-nine HCV-infected patients were treated with pegylated interferon alpha. Diagnosis was based on serum HCV RNA-PCR positive results and liver biopsy. All patients had elevated serum levels of alanine aminotransferase at the time of the study, but liver disease was compensated. Patients were evaluated at baseline treatment and after 4 and 12 weeks of antiviral treatment with the Medical Outcomes Study 36-item Short-Form Health Survey. The Mini-International Neuropsychiatric Interview was used to exclude previous or current psychiatric diagnoses. Both patients and psychiatrists were blind to the HCV RNA status, and serum HCV RNA test results only became available after the visit at week 12. After antiviral treatment, 16 patients (55.2%) were classified as nonresponders and 13 (44.8%) were classified as responders. When compared to nonresponders, responders had a greater improvement in the HRQOL scores for the mental health domain (P < .019). Differences in other domains were not significant. The present study confirms that active viral infection is one possible reason for the poor Health-Related Quality of Life in this population. J. Med. Virol. 80:419–423, 2008. © 2008 Wiley-Liss, Inc.

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