The effect of early virological response in health-related quality of life in HCV-infected patients
Article first published online: 18 JAN 2008
Copyright © 2008 Wiley-Liss, Inc.
Journal of Medical Virology
Volume 80, Issue 3, pages 419–423, March 2008
How to Cite
Quarantini, L. C., Miranda-Scippa, Â., Batista-Neves, S., Galvão-de-Almeida, A., Lacerda, A. L., Moriyama, T. S., Sampaio, A. S., Melcop, A. C., Schinoni, M. I., de Oliveira, I. R., Paraná, R. and Bressan, R. A. (2008), The effect of early virological response in health-related quality of life in HCV-infected patients. J. Med. Virol., 80: 419–423. doi: 10.1002/jmv.21094
- Issue published online: 18 JAN 2008
- Article first published online: 18 JAN 2008
- Manuscript Accepted: 30 OCT 2007
- Foundation for the Support of Research in the State of Bahia. Grant Number: 195712163383
- hepatitis C;
- interferon alpha;
- quality of life;
Twenty-nine HCV-infected patients were treated with pegylated interferon alpha. Diagnosis was based on serum HCV RNA-PCR positive results and liver biopsy. All patients had elevated serum levels of alanine aminotransferase at the time of the study, but liver disease was compensated. Patients were evaluated at baseline treatment and after 4 and 12 weeks of antiviral treatment with the Medical Outcomes Study 36-item Short-Form Health Survey. The Mini-International Neuropsychiatric Interview was used to exclude previous or current psychiatric diagnoses. Both patients and psychiatrists were blind to the HCV RNA status, and serum HCV RNA test results only became available after the visit at week 12. After antiviral treatment, 16 patients (55.2%) were classified as nonresponders and 13 (44.8%) were classified as responders. When compared to nonresponders, responders had a greater improvement in the HRQOL scores for the mental health domain (P < .019). Differences in other domains were not significant. The present study confirms that active viral infection is one possible reason for the poor Health-Related Quality of Life in this population. J. Med. Virol. 80:419–423, 2008. © 2008 Wiley-Liss, Inc.