Molecular epidemiology of hepatitis delta virus (HDV) in Iran: A preliminary report
Version of Record online: 21 OCT 2008
Copyright © 2008 Wiley-Liss, Inc.
Journal of Medical Virology
Volume 80, Issue 12, pages 2092–2099, December 2008
How to Cite
Mohebbi, S. R., Zali, N., Derakhshan, F., Tahami, A., Mashayekhi, R., Amini-Bavil-Olyaee, S. and Zali, M. R. (2008), Molecular epidemiology of hepatitis delta virus (HDV) in Iran: A preliminary report. J. Med. Virol., 80: 2092–2099. doi: 10.1002/jmv.21326
- Issue online: 21 OCT 2008
- Version of Record online: 21 OCT 2008
- Manuscript Accepted: 22 JUL 2008
- Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- hepatitis delta virus;
- phylogenetic analysis;
- molecular epidemiology;
To identify hepatitis delta virus (HDV) genetic variability and its circulating genotypes amongst infected Iranian patients, 25 patients with positive anti-HDV status from different parts of Iran were enrolled in this cross-sectional study. A portion of the HDV delta antigen was amplified, sequenced, and subjected to molecular and phylogenetic analysis. Clinical features and virological markers were evaluated. HDV RNA could be detected in 88% of anti-HDV positive cases (22 patients) with chronic hepatitis B virus (HBV) infection and liver cirrhosis. Phylogenetic analysis revealed that all Iranian patients were infected by genotype I (clade 1) of HDV, supported by a high bootstrap value (100%, 1,000 replicates). All HDV-positive patients were coinfected with genotype D1 of HBV. No significant association was determined between demographic, clinical, and virological variables in the population studied. In conclusion, the present molecular epidemiology survey reveals that clade 1 of HDV is predominant among coinfected HBV patients in Iran. J. Med. Virol. 80:2092–2099, 2008. © 2008 Wiley-Liss, Inc.