Human leukocyte antigen-DRB1*1101 correlates with less severe hepatitis in Taiwanese male carriers of hepatitis B virus

Authors

  • Yi-Wen Huang,

    1. Liver Unit, Cathay General Hospital Medical Center, Taipei, Taiwan
    2. Division of Gastroenterology, Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    Search for more papers by this author
  • Chung-Yi Hu,

    1. Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan
    Search for more papers by this author
  • Chi-Lin Chen,

    1. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
    Search for more papers by this author
  • Ya-Tang Liao,

    1. Graduate Institute of Epidemiology, National Taiwan University College of Medicine, Taipei, Taiwan
    Search for more papers by this author
  • Chun-Jen Liu,

    1. Division of Gastroenterology, Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    2. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
    Search for more papers by this author
  • Ming-Yang Lai,

    1. Division of Gastroenterology, Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    2. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
    Search for more papers by this author
  • Pei-Jer Chen,

    1. Division of Gastroenterology, Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    2. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
    Search for more papers by this author
  • Sien-Sing Yang,

    1. Liver Unit, Cathay General Hospital Medical Center, Taipei, Taiwan
    Search for more papers by this author
  • Jui-Ting Hu,

    1. Liver Unit, Cathay General Hospital Medical Center, Taipei, Taiwan
    Search for more papers by this author
  • Ding-Shinn Chen,

    1. Division of Gastroenterology, Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    2. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
    Search for more papers by this author
  • Jia-Horng Kao

    Corresponding author
    1. Division of Gastroenterology, Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    2. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
    3. Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan
    • Director and Distinguished Professor, Hepatitis Research Center, National Taiwan University Hospital, Chung-Shan South Road, Taipei 10002, Taiwan.
    Search for more papers by this author

  • Part of the study had been presented in the 17th Asian Pacific Association for the Study of the Liver (APASL) conference, March 2007, Kyoto, Japan (oral abstract O-007, Hepatol Int 2007;1:4).

Abstract

Human leukocyte antigen (HLA) class II molecules are associated with host immune responses against hepatitis B virus infection. Male gender is the apparent host factor when someone encounters with the severity of hepatitis. The aim of this study was to investigate the association of the most polymorphic HLA class II allele, human leukocyte antigen—DRB1, with the severity of hepatitis in male carriers of hepatitis B virus. In this prospective cohort study, a total of 204 carriers of hepatitis B virus (131 men and 73 women) who have been followed-up for more than 1 year at the outpatient clinic of a university hospital were collected consecutively. Fifty carriers of hepatitis B virus (group I) with alanine aminotransferase <2× upper limit of normal (mean follow-up 83.6 months) were compared with 154 chronic hepatitis B patients (group II) with alanine aminotransferase ≥2× upper limit of normal (mean follow-up 81.3 months). Alleles of HLA-DRB1 were typed by the polymerase chain reaction—sequence specific oligonucleotide probe hybridization and genotypes of hepatitis B virus by melting curve analysis. HLA-DRB1*1101 was found in 18% of group I versus 8% of group II in male carriers (OR 0.23, P = 0.020, after adjustment for age) and 4% versus 9.4% in female carriers (P = 0.094). In male carriers harboring DRB1*1101, the distribution of hepatitis B viral genotype was comparable between the two groups. HLA-DRB1*1101 correlates with less severe hepatitis in Taiwanese male carriers of hepatitis B virus. J. Med. Virol. 81:588–593, 2009 © 2009 Wiley-Liss, Inc.

Ancillary