Authors have no financial or other conflict of interest to disclose.
Long-term outcome of hepatitis B and hepatitis C virus co-infection and single HBV infection acquired in youth†
Article first published online: 25 OCT 2009
Copyright © 2009 Wiley-Liss, Inc.
Journal of Medical Virology
Volume 81, Issue 12, pages 2012–2020, December 2009
How to Cite
Zampino, R., Marrone, A., Merola, A., Trani, B., Cirillo, G., Karayiannis, P., Coppola, N., Zappalà, R., Utili, R., Ruggiero, G. and Adinolfi, L. E. (2009), Long-term outcome of hepatitis B and hepatitis C virus co-infection and single HBV infection acquired in youth. J. Med. Virol., 81: 2012–2020. doi: 10.1002/jmv.21560
- Issue published online: 25 OCT 2009
- Article first published online: 25 OCT 2009
- Manuscript Accepted: 5 MAY 2009
- Regione Campania, Italy
- HBV–HCV co-infection;
- chronic hepatitis;
- long-term outcome
Co-infection with HBV and HCV seems to be associated with more severe liver disease in retrospective and cross-sectional studies in adults, but no data are available when co-infection is acquired in youth. The long-term outcome of infection acquired in youth was assessed in patients co-infected with HBV and HCV and in patients with HBV infection only. Twenty-seven patients with HBV and HCV co-infection and 27 patients infected with HBV only were enrolled. Seventy-six per cent of the patients were treated with α-interferon for 1 year. After a median follow-up of 23 years, the annual progression rate of fibrosis was 0.07 in patients co-infected with HBV and HCV, and in those infected with HBV it was 0.07 and 0.11 (P < 0.004) for HBe and anti-HBe-positive patients, respectively. In co-infected patients, the development of cirrhosis was observed in 2 (7.4%) and of hepatocellular carcinoma (HCC) in 1 (3.7%), while in those with HBV, cirrhosis appeared in one patient (3.7%). Alcohol intake (OR = 9.5 ± 1.2; 95% CI = 6.6–13.9; P < 0.0001) was independently associated with cirrhosis and HCC. α-interferon showed no efficacy during treatment, but the treated group showed higher HCV RNA clearance during post-treatment follow-up. Co-infection with HBV and HCV and single HBV infection acquired in youth showed a low rate of progression to liver fibrosis, no liver failure, and low development of HCC during a median follow-up of 23 years (range 17–40). J. Med. Virol. 81:2012–2020, 2009. © 2009 Wiley-Liss, Inc.