Research Article

Detection of a new yellow fever virus lineage within the South American genotype I in Brazil

  1. Renato P. de Souza1,
  2. Peter G. Foster2,
  3. Maria Anice M. Sallum3,
  4. Terezinha L.M. Coimbra1,
  5. Adriana Y. Maeda1,
  6. Vivian R. Silveira1,
  7. Eduardo S. Moreno1,
  8. Fernanda G. da Silva1,
  9. Iray M. Rocco1,
  10. Ivani B. Ferreira1,
  11. Akemi Suzuki1,
  12. Fabíola M. Oshiro1,
  13. Selma M.C.N. Petrella1,
  14. Luiz E. Pereira1,
  15. Giselda Katz4,
  16. Cilea H. Tengan4,
  17. Melissa M. Siciliano4,
  18. Cecília L.S. dos Santos1,*

Article first published online: 30 NOV 2009

DOI: 10.1002/jmv.21606

Issue

Journal of Medical Virology

Journal of Medical Virology

Volume 82, Issue 1, pages 175–185, January 2010

Additional Information

How to Cite

de Souza, R. P., Foster, P. G., Sallum, M. A. M., Coimbra, T. L., Maeda, A. Y., Silveira, V. R., Moreno, E. S., da Silva, F. G., Rocco, I. M., Ferreira, I. B., Suzuki, A., Oshiro, F. M., Petrella, S. M., Pereira, L. E., Katz, G., Tengan, C. H., Siciliano, M. M. and dos Santos, C. L. (2010), Detection of a new yellow fever virus lineage within the South American genotype I in Brazil. Journal of Medical Virology, 82: 175–185. doi: 10.1002/jmv.21606

Author Information

  1. 1

    Serviço de Virologia do Instituto Adolfo Lutz, São Paulo, SP, Brazil

  2. 2

    Department of Zoology, Natural History Museum, London, United Kingdom

  3. 3

    Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SP, Brazil

  4. 4

    Divisão de Zoonoses, Centro de Vigilância Epidemiológica, São Paulo, SP, Brazil

*Serviço de Virologia do Instituto Adolfo Lutz, Av. Dr. Arnaldo 355, CEP 01246/902 São Paulo, SP, Brazil.

Publication History

  1. Issue published online: 30 NOV 2009
  2. Article first published online: 30 NOV 2009
  3. Manuscript Accepted: 21 JUN 2009

Funded by

  • Secretaria de Estado da Saude de São Paulo/SP
  • FAPESP (to C.L.S.S. and M.A.M.S.). Grant Number: 05/53973-0

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Keywords:

  • yellow fever virus;
  • subclade 1;
  • premembrane and envelope gene junction;
  • 3′ non-coding region;
  • molecular clock;
  • divergence time

Abstract

Nucleotide sequences of two regions of the genomes of 11 yellow fever virus (YFV) samples isolated from monkeys or humans with symptomatic yellow fever (YF) in Brazil in 2000, 2004, and 2008 were determined with the objective of establishing the genotypes and studying the genetic variation. Results of the Bayesian phylogenetic analysis showed that sequences generated from strains from 2004 and 2008 formed a new subclade within the clade 1 of the South American genotype I. The new subgroup is here designated as 1E. Sequences of YFV strains recovered in 2000 belong to the subclade 1D, which comprises previously characterized YFV strains from Brazil. Molecular dating analyses suggested that the new subclade 1E started diversifying from 1D about 1975 and that the most recent 2004–2008 isolates arose about 1985. J. Med. Virol. 82:175–185, 2010. © 2009 Wiley-Liss, Inc.

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