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Research Article

Virus clearance reduces bone fracture in postmenopausal women with osteoporosis and chronic liver disease caused by hepatitis C virus

  1. Yasuji Arase1,2,3,*,
  2. Fumitaka Suzuki1,
  3. Yoshiyuki Suzuki1,
  4. Norio Akuta1,
  5. Masahiro Kobayashi1,
  6. Hitomi Sezaki1,
  7. Tetsuya Hosaka1,
  8. Yusuke Kawamura1,
  9. Hiromi Yatsuji1,
  10. Miharu Hirakawa1,
  11. Kenji Ikeda1,
  12. Shiun Dong Hsieh2,
  13. Yuki Oomoto2,
  14. Kazuhisa Amakawa2,
  15. Hisahito Kato2,
  16. Tamae Kazawa2,
  17. Hiroshi Tsuji2,
  18. Tetsuro Kobayashi3,
  19. Hiromitsu Kumada1

Article first published online: 19 JAN 2010

DOI: 10.1002/jmv.21691

Issue

Journal of Medical Virology

Journal of Medical Virology

Volume 82, Issue 3, pages 390–395, March 2010

Additional Information

How to Cite

Arase, Y., Suzuki, F., Suzuki, Y., Akuta, N., Kobayashi, M., Sezaki, H., Hosaka, T., Kawamura, Y., Yatsuji, H., Hirakawa, M., Ikeda, K., Hsieh, S. D., Oomoto, Y., Amakawa, K., Kato, H., Kazawa, T., Tsuji, H., Kobayashi, T. and Kumada, H. (2010), Virus clearance reduces bone fracture in postmenopausal women with osteoporosis and chronic liver disease caused by hepatitis C virus. J. Med. Virol., 82: 390–395. doi: 10.1002/jmv.21691

Author Information

  1. 1

    Department of Hepatology and Okinaka Memorial Institute for Medical Research Toranomon Hospital, Tokyo, Japan

  2. 2

    Health Management Center, Toranomon Hospital, Tokyo, Japan

  3. 3

    Third Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan

*Department of Hepatology, Toranomon Hospital, 2-2-2, Toranomon, Minato-ku, Tokyo 105-8470, Japan.

Publication History

  1. Issue published online: 19 JAN 2010
  2. Article first published online: 19 JAN 2010
  3. Manuscript Accepted: 10 SEP 2009

Funded by

  • Japanese Ministry of Health, Labour and Welfare (partial support)

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Keywords:

  • chronic hepatitis C;
  • osteoporosis;
  • interferon;
  • bone fracture

Abstract

Osteoporosis is often present in postmenopausal women. The aim of this retrospective cohort study was to assess the cumulative incidence and predictive factors for bone fracture after cessation of interferon (IFN) in postmenopausal women with osteoporosis and chronic liver disease caused by hepatitis C virus (HCV). A total of 420 postmenopausal women treated with IFN monotherapy were enrolled. The mean observation period was 7.2 years. The primary goal was the development of bone fracture. Evaluation was carried out by using the Kaplan–Meier method and the Cox proportional hazards analysis. Thirty-one out of 420 patients sustained bone fracture. The cumulative development rate of bone fracture was 3.6% at 5th year, 9.2% at 10th year, and 17.4% at 15th year. Multivariate Cox proportional hazards analysis showed that bone fracture after cessation of IFN therapy occurred when histological staging of the liver was advanced (hazard ratio (HR): 2.54; 95% confidence interval (CI) = 1.21–5.31; P = 0.013), serum albumin level was < 3.5g/dl (HR: 2.25; 95% CI = 1.10–4.59; P = 0.026), and virus clearance was not achieved (HR: 3.65; 95% CI = 1.11–12.05; P = 0.033). The results indicate that virus clearance causes a reduction of two-thirds in the risk of bone fracture after cessation of IFN therapy in postmenopausal women with osteoporosis and chronic liver disease caused by HCV. J. Med. Virol. 82:390–395, 2010. © 2010 Wiley-Liss, Inc.

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