Authors have no conflict of interest related to this article.
Human metapneumovirus genotypes and severity of disease in young children (n = 100) during a 7-year study in Dijon hospital, France†
Article first published online: 1 SEP 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Medical Virology
Volume 82, Issue 10, pages 1782–1789, October 2010
How to Cite
Pitoiset, C., Darniot, M., Huet, F., Aho, S.-L., Pothier, P. and Manoha, C. (2010), Human metapneumovirus genotypes and severity of disease in young children (n = 100) during a 7-year study in Dijon hospital, France. J. Med. Virol., 82: 1782–1789. doi: 10.1002/jmv.21884
- Issue published online: 1 SEP 2010
- Article first published online: 1 SEP 2010
- Manuscript Accepted: 28 MAY 2010
- human metapneumovirus;
Human metapneumovirus is a cause of respiratory tract infections at all ages. Our objectives were to analyze the distribution of the A and B genotypes over 7 years in Dijon and to investigate a possible association between hMPV genotypes and disease severity. During 2002–2009, we genotyped the 100 isolates from children <3 years old with hMPV. Phylogenetic analysis indicated a change in the distribution of hMPV genotype over the years. Severity was then measured by detailed clinical evaluation. The hospitalization rate was greater when genotype B was involved 72.5% versus 53.3% (P = 0.054). Those infected with genotype B tended to have a higher clinical score, as measured by Vicente et al. 2006 (P = 0.07). We showed that, although clinical severity is not clearly associated with hMPV genotype in this study, pathological signs on chest X-ray were observed more often in B subgroup (P < 0.01). J. Med. Virol. 82:1782–1789, 2010. © 2010 Wiley-Liss, Inc.