The authors have no financial or other conflicts of interest to declare in relation to this paper. No financial support was required for this paper.
Clinical characteristics of hepatitis E in a “Non-Endemic” population†
Article first published online: 17 SEP 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Medical Virology
Volume 82, Issue 11, pages 1899–1902, November 2010
How to Cite
Turner, J., Godkin, A., Neville, P., Kingham, J. and Ch'ng, C. L. (2010), Clinical characteristics of hepatitis E in a “Non-Endemic” population. J. Med. Virol., 82: 1899–1902. doi: 10.1002/jmv.21905
- Issue published online: 17 SEP 2010
- Article first published online: 17 SEP 2010
- Manuscript Accepted: 29 JUN 2010
- acute hepatitis;
- liver function tests
Hepatitis E virus (HEV) is a ribonucleic acid (RNA) virus with predominant fecal oral spread. Traditionally in Western Europe it is associated with travel to endemic countries, but an increasing number of locally acquired cases have been reported throughout England. Patients presenting with acute non-travel associated HEV infection in south Wales over a 25-month period were monitored, in an attempt to understand the clinical picture and epidemiology in our patient population. Twenty-four patients were identified with non-travel associated HEV infection and studied prospectively. Patient demographics, symptoms, and serial laboratory results were recorded. There was a male/female ratio of 3:1, with a median patient age of 65.5 years old. Patients developed a significant icteric hepatitis (median peak bilirubin: 139 µmol/L, median peak AST: 1,973 IU/L and ALT: 2,021 IU/L), with liver function remaining abnormal for ∼7 weeks. All patients in whom HEV RNA was isolated were infected with genotype 3. Forty-six percent of patients presented during winter months. The data show a group mortality rate of 4.2%, similar to that reported in endemic countries. HEV results in a severe and occasionally fatal hepatitis. Testing for hepatitis E is now recommended in any patient presenting with acute hepatitis of unknown etiology. J. Med. Virol. 82:1899–1902, 2010. © 2010 Wiley-Liss, Inc.