Research Article

Symptomatic and asymptomatic infections of rotavirus, norovirus, and adenovirus among hospitalized children in Xi'an, China†

  1. Shuwan Zhang1,
  2. Tsun-Hsuan Chen2,
  3. Juan Wang3,
  4. Changxin Dong2,
  5. Jingjing Pan1,
  6. Christine Moe2,
  7. Wei Chen1,
  8. Lihong Yang1,
  9. Xiaoqin Wang4,
  10. Helen Tang2,
  11. Xu Li1,
  12. Pengbo Liu1,2,*

Article first published online: 26 MAY 2011

DOI: 10.1002/jmv.22108

Issue

Journal of Medical Virology

Journal of Medical Virology

Volume 83, Issue 8, pages 1476–1484, August 2011

Additional Information

How to Cite

Zhang, S., Chen, T.-H., Wang, J., Dong, C., Pan, J., Moe, C., Chen, W., Yang, L., Wang, X., Tang, H., Li, X. and Liu, P. (2011), Symptomatic and asymptomatic infections of rotavirus, norovirus, and adenovirus among hospitalized children in Xi'an, China. J. Med. Virol., 83: 1476–1484. doi: 10.1002/jmv.22108

Author Information

  1. 1

    The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

  2. 2

    Rollins School of Public Health of Emory University, Atlanta, Georgia

  3. 3

    Xi'an Children's Hospital, Xi'an, China

  4. 4

    School of Public Health, Xi'an Jiaotong University, Xi'an, China

*The First Affiliated Hospital, Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, China.

  1. †

    Shuwan Zhang and Tsun-Hsuan Chen contribute equally to this work.

Publication History

  1. Issue published online: 15 JUN 2011
  2. Article first published online: 26 MAY 2011
  3. Manuscript Accepted: 27 MAR 2011

Funded by

  • National Natural Science Foundation of China (partial support). Grant Number: 30940059
  • Global Field Experience (GFE) program in the Rollins School of Public Health of Emory University, USA

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Keywords:

  • rotavirus;
  • norovirus;
  • adenovirus;
  • diarrhea;
  • asymptomatic infection

Abstract

Rotavirus (RV), norovirus (NoV), and adenovirus (AdV) have been reported as the common viral pathogens of acute gastroenteritis in children. To determine the prevalence of RV, NoV, and AdV infections among hospitalized children with and without symptoms of acute gastroenteritis, fecal specimens, and data on clinical symptoms were collected from 201 children with diarrhea and 53 children without diarrhea admitted to the Xi'an Children's Hospital in Xi'an, China between March 2009 and May 2010. RV, NoV, and AdV were identified in 68.7% (138/201), 20.4% (41/201), and 5.0% (10/201), respectively, of children with diarrhea. These three viruses were also detected in 13.2% (7/53), 35.9% (19/53), and 9.4% (6/53), respectively, of children without diarrhea. Diarrheal children infected with RV alone showed the average severity score of 6.5, statistically significant higher than the average score of 5.3 in children with unidentifiable viruses. GII.3 and GII.4 were the only two NoV genotypes identified, and the GII.4 sequences were genetically close to GII.4 2006b cluster. These findings highlight the importance of NoV as a causative agent of pediatric diarrhea after RV based on the clinical and epidemiological characteristics of NoV infection, and particularly convey information of asymptomatic infections of enteric viruses in young children. J. Med. Virol. 83:1476–1484, 2011. © 2011 Wiley-Liss, Inc.

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