Conflict of interest: The authors declare that they have no competing interests.
Hepatitis E virus infection in patients infected with the human immunodeficiency virus†
Article first published online: 11 AUG 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Medical Virology
Volume 83, Issue 10, pages 1704–1716, October 2011
How to Cite
Kaba, M., Richet, H., Ravaux, I., Moreau, J., Poizot-Martin, I., Motte, A., Nicolino-Brunet, C., Dignat-George, F., Ménard, A., Dhiver, C., Brouqui, P. and Colson, P. (2011), Hepatitis E virus infection in patients infected with the human immunodeficiency virus. J. Med. Virol., 83: 1704–1716. doi: 10.1002/jmv.22177
- Issue published online: 9 AUG 2011
- Article first published online: 11 AUG 2011
- Manuscript Accepted: 8 JUN 2011
- hepatitis E virus;
- human immunodeficiency virus;
- chronic HEV infection;
- autochthonous transmission
Hepatitis E virus (HEV) is a newly-identified causative agent of acute and chronic hepatitis in severely immunocompromized patients. The present study sought to assess the prevalences of past, recent, on-going, and chronic HEV infections in patients infected with human immunodeficiency virus (HIV) in Marseille, South-eastern France, and to determine if they were correlated with the patients' immunological status or with cirrhosis. Anti-HEV IgG and IgM and HEV RNA testing were concurrently performed on the plasma from 184 patients infected with HIV, including 81 with a CD4+ T-lymphocyte count (CD4 count) <50 cells/mm3 and 32 with a cirrhosis. Prevalence of anti-HEV IgG and IgM was 4.4% (8/184) and 1.6% (3/184), respectively. Past, recent, and on-going infections were observed in 3.3% (6/184), 1.6% (3/184), and 0.5% (1/184) of the patients, respectively. Anti-HEV antibodies prevalence did not differ significantly according to CD4 count, cirrhosis, sex, age, mode of HIV transmission, and infection with hepatitis B or C virus. Anti-HEV IgG seroreversion was observed in two patients. The patient whose plasma tested positive for HEV RNA had a CD4 count <50 cells/mm3; HEV genotype was 3f. In this patient, longitudinal testing showed HEV RNA positivity during a 10-month period, indicating chronic HEV infection; in contrast, anti-HEV IgG never tested positive. Further studies are needed to evaluate the performance of commercial HEV serological assays in patients infected with HIV and to assess the actual incidence, prevalence, and outcome of HEV infection in this special group of patients. HEV RNA testing is necessary for such purposes. J. Med. Virol. 83:1704–1716, 2011. © 2011 Wiley-Liss, Inc.