Molecular epidemiology of measles virus in Iran 2009–2010: First detection of measles genotype H1
Article first published online: 19 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Medical Virology
Volume 83, Issue 12, pages 2200–2207, December 2011
How to Cite
Salimi, V., Mokhtari-Azad, T., Abbasi, S., NoroozBabaei, Z., Soltan-Shahi, R., Zahraie, M., Bont, L. and Gouya, M. M. (2011), Molecular epidemiology of measles virus in Iran 2009–2010: First detection of measles genotype H1. J. Med. Virol., 83: 2200–2207. doi: 10.1002/jmv.22220
- Issue published online: 19 OCT 2011
- Article first published online: 19 OCT 2011
- Manuscript Accepted: 26 JUL 2011
- Iran National Science Foundation (INSF). Grant Number: 85022/8
- genetic characterization;
- measles genotyping;
Measles virus (MV) genotyping is an important component of measles surveillance in the context of monitoring immunization program effectiveness and documenting MV elimination. The molecular epidemiology and genetic variability of circulating MV strains in Iran during the 2009–2010 were studied in consecutive MV isolates from throat swab and urine. Sequence information obtained from 41 cases based on the 456 nucleotides of the most variable region of the C-terminal part of the N-protein revealed that these sequences belonged to two different genotypes. This is the first description of the genetic characterization of sporadic MV genotype H1 cases in northern Iran. Cases were probably linked to MV importation from distant parts of Asia. The genotype H1 has not been detected in the Eastern Mediterranean Region. In addition, both sequence analysis and epidemiologic data indicated that the more recently detected genotype D4 viruses in Iran were related very closely to viruses that were detected in Pakistan, suggesting that these viruses may have been imported from Pakistan. J. Med. Virol. 83:2200–2207, 2011. © 2011 Wiley Periodicals, Inc.