None of the authors has commercial or other associations that might pose a conflict of interest.
Hepatitis A Virus genotype and its correlation with the clinical outcome of acute hepatitis A in Korea: 2006–2008†
Article first published online: 19 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Medical Virology
Volume 83, Issue 12, pages 2073–2081, December 2011
How to Cite
Yun, H., Lee, H. J., Jang, J.-H., Kim, J. S., Lee, S. H., Kim, J.-W., Park, S. J., Park, Y. M., Hwang, S. G., Rim, K. S., Kang, S.-K., Lee, H. S. and Jeong, S.-H. (2011), Hepatitis A Virus genotype and its correlation with the clinical outcome of acute hepatitis A in Korea: 2006–2008. J. Med. Virol., 83: 2073–2081. doi: 10.1002/jmv.22229
- Issue published online: 19 OCT 2011
- Article first published online: 19 OCT 2011
- Manuscript Accepted: 4 AUG 2011
- Korean Association for the Study of Liver and the Korea National Institute of Health (KNIH; Intramural Fund) 4800-4863-300
- acute viral hepatitis;
- hepatitis A virus;
Korea has recently experienced a nationwide outbreak of hepatitis A. This study aimed to investigate hepatitis A virus (HAV) genotypes and to compare clinical features between patients infected with HAV genotype IA and those with genotype IIIA. From September 2006 to August 2008, 595 patients with symptomatic hepatitis A were enrolled prospectively in four hospitals in Korea. Among them, 556 patients participated in this study by providing serum or stool samples for genotypic analysis. HAV RNA was detected in 499 patients (89.7%). Major genotypes included IA (n = 244, 48.9%) and IIIA (n = 244, 48.9%), and the remaining genotype was IB (n = 11, 2.2%). From September 2006 to August 2007, the distribution of genotypes IA and IIIA were 64.6% and 35.6%, respectively, which changed to 42.3% and 54.6%, respectively, from September 2007 to August 2008, indicating change of circulating HAV genotypes in the study period from IA to IIIA. Major patterns of amino acid substitution in the VP3/VP1 junction region were observed at position 512 (P L) in genotype IA and at 520 (R K) in genotype IIIA. Patients with genotype IIIA infection showed significantly higher aminotransferase levels, prothrombin time, and leukocyte count, with more severe symptoms than those with genotype IA at the time of admission. These results suggest the occurrence of a change of circulating HAV genotypes in recent community-wide outbreaks of hepatitis A in Korea, and genotype IIIA infection, compared with genotype IA infection, might show more severe clinical manifestations. J. Med. Virol. 83:2073–2081, 2011. © 2011 Wiley Periodicals, Inc.