Near-full genome characterization of unclassified hepatitis c virus strains relating to genotypes 1 and 4
Version of Record online: 19 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Medical Virology
Volume 83, Issue 12, pages 2119–2127, December 2011
How to Cite
Demetriou, V. L. and Kostrikis, L. G. (2011), Near-full genome characterization of unclassified hepatitis c virus strains relating to genotypes 1 and 4. J. Med. Virol., 83: 2119–2127. doi: 10.1002/jmv.22237
- Issue online: 19 OCT 2011
- Version of Record online: 19 OCT 2011
- Manuscript Accepted: 17 AUG 2011
- Cyprus Research Promotion Foundation. Grant Number: ENIΣX/0506/34
- University of Cyprus
- BIRCH Biomedical
- HCV subtype classification;
- near-full genome sequencing
Near-full genome sequences are presented in this report for the first time of unclassified HCV strains amplified using RT-PCR from plasma of patients living in Cyprus. One strain appears to be a unique genotype-1-like isolate, displaying closer phylogenetic relationship to genotype 1 strains than other genotypes. Two isolates representing an unclassified variant of genotype 4 were also amplified, cases of which have been found elsewhere in the world in patients of central African origin and could now be assigned provisionally as new subtype 4v. The near-full genome nucleotide sequences of unclassified HCV isolates provide reference sequences of variants unknown previously, and contribute to the publicly available HCV sequence data to be used for diagnosis or research. J. Med. Virol. 83:2119–2127, 2011. © 2011 Wiley Periodicals, Inc.