The authors have no commercial or other association that might pose a conflict of interest related to this study or its publication.
Dynamics of urinary polyomavirus shedding in healthy adult women†
Article first published online: 18 JUL 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Medical Virology
Volume 84, Issue 9, pages 1459–1463, September 2012
How to Cite
Kling, C. L., Wright, A. T., Katz, S. E., McClure, G. B., Gardner, J. S., Williams, J. T., Meinerz, N. M., Garcea, R. L. and Vanchiere, J. A. (2012), Dynamics of urinary polyomavirus shedding in healthy adult women. J. Med. Virol., 84: 1459–1463. doi: 10.1002/jmv.23319
- Issue published online: 18 JUL 2012
- Article first published online: 18 JUL 2012
- Manuscript Accepted: 17 APR 2012
- National Center for Research Resources. Grant Number: 5P20RR018724-10
- National Institute of General Medical Sciences. Grant Number: 8 P20 GM103433-10
- National Institutes of Health to the Center for Molecular and Tumor Virology at LSUHSC-S
- Department of Pediatrics at LSUHSC-S
- BK virus;
- menstrual cycle;
- JC virus
The hypothesis was examined that physiologic variation of estrogen concentrations during the menstrual cycle can provoke BK virus (BKV) excretion. BKV and JCV viral loads were determined in urine specimens obtained almost daily from 20 healthy, non-pregnant women over 2 months. Asymptomatic urinary shedding of BKV was observed in 123 (12.0%) of 1,021 specimens from 11 (55%) study subjects. Two subjects excreted JCV in their urine, with one subject excreting detectable JCV in all urine specimens. Analysis of 36 complete menstrual cycles revealed no difference in the prevalence of BKV excretion between pre-ovulatory and post-ovulatory phases of the menstrual cycle. The unexpected day-to-day variability in BKV excretion suggests that as yet unidentified factors may contribute to the periodic shedding of BKV by healthy women. J. Med. Virol. 84:1459–1463, 2012. © 2012 Wiley Periodicals, Inc.