Members of the SEIEVA collaborating group are listed in the online version of this article.
Risk factors for and incidence of acute hepatitis C after the achievement of blood supply safety in Italy: Results from the national surveillance system†
Version of Record online: 28 DEC 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Medical Virology
Volume 85, Issue 3, pages 433–440, March 2013
How to Cite
Spada, E., Mele, A., Mariano, A., Zuccaro, O., Tosti, M. E. and on behalf of SEIEVA collaborating group (2013), Risk factors for and incidence of acute hepatitis C after the achievement of blood supply safety in Italy: Results from the national surveillance system. J. Med. Virol., 85: 433–440. doi: 10.1002/jmv.23485
The authors have no conflict of interest.
- Issue online: 22 JAN 2013
- Version of Record online: 28 DEC 2012
- Manuscript Accepted: 30 OCT 2012
- “Sorveglianze speciali” of the Italian Ministry of the Health (Progetto CCM e Istituto Superiore di Sanità-Fasc. ISS 1M56 14/09/2010-13/09/2012)
- acute hepatitis;
Surveillance systems for acute hepatitis C allow monitoring of disease incidence trends and transmission patterns. This study aimed to describe the epidemiological profile of reported cases of symptomatic acute hepatitis C in Italy after the achievement of blood supply safety. The incidence of symptomatic acute hepatitis C since 1991 was estimated. Risk factors for acute hepatitis C were analyzed for the period 2003–2010 through a case–control study within a population-based surveillance for acute viral hepatitis. From 1991 to 2010, the incidence decreased from 2 to 0.2 per 100,000, with a more evident decrease among persons aged 15–24 years. During 2003–2010, 1,053 cases were reported. Intravenous drug use (adjusted odds ratio [adjOR], 30.5; 95% confidence interval [CI], 18.9–49.1), cohabitation or sexual partnership with an hepatitis C virus (HCV) carrier (adjOR, 11.2; 95% CI, 6.6–19.2), nosocomial exposure (adjOR, 6.6; 95% CI, 4.6–9.4); unsafe sexual practices (adjOR, 3.1; 95% CI, 1.9–5.2), and cosmetic treatments with percutaneous exposure (adjOR, 1.7; 95% CI, 1.2–2.4) were independently associated with acute hepatitis C. Population attributable risk estimates indicated nosocomial exposure (39.6%) and intravenous drug use (30.5%) as responsible for most cases. In conclusion, the incidence of symptomatic acute hepatitis C is declining in Italy. Currently, the most important risk factors are: having an HCV-positive household or sexual partner, unsafe sexual practices, cosmetic percutaneous treatments, intravenous drug use, and nosocomial exposure; the latter two factors are responsible for most cases. Effective prevention programs for intravenous drug users and strict adherence to universal precautions in healthcare settings are needed. J. Med. Virol. 85:433–440, 2013. © 2012 Wiley Periodicals, Inc.