Conflict of interest: None.
Clinical and epidemiological features of hepatitis C virus infection in South Korea: A prospective, multicenter cohort study†
Article first published online: 28 JUN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Medical Virology
Volume 85, Issue 10, pages 1724–1733, October 2013
How to Cite
Seong, M. H., Kil, H., Kim, Y. S., Bae, S. H., Lee, Y. J., Lee, H. C., Kang, B. H. and Jeong, S.-H. (2013), Clinical and epidemiological features of hepatitis C virus infection in South Korea: A prospective, multicenter cohort study. J. Med. Virol., 85: 1724–1733. doi: 10.1002/jmv.23661
- Issue published online: 29 JUL 2013
- Article first published online: 28 JUN 2013
- Manuscript Accepted: 22 APR 2013
- Korea National Institute of Health (KNIH Extramural fund). Grant Number: 2012-E4-200300
- hepatitis C virus;
The epidemiological and clinical features of hepatitis C virus (HCV) infection in South Korea were examined in a prospective, multicenter cohort study that included 1,173 adult patients with positive results for anti-HCV antibody who completed a questionnaire survey on the risk factors for HCV infection from January 2007 to December 2011 at five university hospitals. The HCV cohort had a mean age of 55.4 years with 48.3% men, and diagnostic categories of acute hepatitis (n = 63, 5.3%), past infection (n = 37, 3.2%), chronic hepatitis (n = 777, 66.2%), cirrhosis of the liver (n = 179, 15.3%), and hepatocellular carcinoma (n = 117, 10.0%). The major HCV genotypes were genotype 1 (52.7%) and genotype 2 (45.3%). Liver biopsy was performed in 301 patients (25.7%), and 42.8% of the subjects received antiviral therapy against HCV. The behavioral risk factors possibly related to HCV infection were intravenous drug use (5%), needle stick injury (7%), blood transfusion before 1995 (19%), sexual relationship with more than three partners (28%), piercings (35%), tattoos (36%), surgery (43%), acupuncture (83%), diagnostic endoscopy (85%), and dental procedures (93%). Age, intravenous drug use, needle stick injury, transfusion before 1995, and tattoos were the independent risk factors of HCV infection. J Med. Virol. 85:1724–1733, 2013. © 2013 Wiley Periodicals, Inc.