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REFERENCES

  • Auer IA, Schmidt ML, Lee VM, Curry B, Suzuki K, Shin RW, Pentchev PG, Carstea ED, Trojanowski JQ. 1995. Paired helical filament tau (PHF tau) in Niemann-Pick type C disease is similar to PHF tau in Alzheimer's disease. Acta Neuropathol 90: 547551.
  • Bodovitz S, Klein WL. 1996. Cholesterol modulates α-secretase cleavage of amyloid precursor protein. J Biol Chem 271: 44364440.
  • Cenedella RJ, Shi H. 1994. Spatial distribution of 3-hydroxy-3 methylglutaryl coenzyme A reductase messenger RNA in the ocular lens: relationship to cholesterogenesis. J Lipid Res 23: 619626.
  • Corder EH, Sauders AM, Strittmatter WJ, Schmechel DE, Gaskell GW, Small GW, Roses AD, Haines JL, Pericak-Vance MA. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261: 921923.
  • Dietschy JM, Turley SD. 2001. Cholesterol metabolism in the brain. Curr Opin Lipidol 12: 105112.
  • Distl R, Meske V, Ohm TG. 2001. Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons. Acta Neuropathol (Berl) 101: 547554.
  • Evans RM, Emsley CL, Gao S, Sahota A, Hall KS, Farlow MR, Hendrie H. 2000. Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a population-based study of African Americans. Neurology 54: 240242.
  • Fan QW, Yu W, Senda T, Yanagisawa K, Michikawa M. 2001. Cholesterol-dependent modulation of tau phosphorylation in cultured neurons. J Neurochem 76: 391400.
  • Fassbender K, Simons M, Bergmann C, Stroick M, Lutjohann D, Keller P, Runz H, Kuhl S, Bertsch T, von Bergmann K, Hennerici M, Beyreuther K, Hartmann T. 2001. Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ 42 and Aβ 40 in vitro and in vivo. Proc Natl Acad Sci USA 98: 58565861.
  • Frears ER, Stephens DJ, Walters CE, Davies H, Austen BM. 1999. The role of cholesterol in the biosynthesis of β-amyloid. NeuroReport 10: 16991705.
  • Goodrum JF. 1990. Cholesterol synthesis is down-regulated during regeneration of peripheral nerve. J Neurochem 54: 17091715.
  • Hayashi H, Igbavboa U, Hamanaka H, Kobayashi M, Fujita SC, Wood WG, Yanagisawa K. 2002. Cholesterol is increased in the exofacial leaflets of synaptic plasma membranes of human apolipoprotein ϵ4 knock-in mice. NeuroReport (in press).
  • Hofman A, Ott A, Breteler MM, Bots ML, Slooter AJ, van Harskamp F, van Duijn CN, Van Broeckhoven C, Grobbee DE. 1997. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet 349: 151154.
  • Igbavboa U, Avdulov NA, Schroeder F, Wood WG. 1996. Increasing age alters transbilayer fluidity and cholesterol asymmetry in synaptic plasma membranes of mice. J Neurochem 66: 17171725.
  • Jarvik GP, Wijsman EM, Kukull WA, Schellenberg GD, Yu C, Larson EB. 1995. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology 45: 10921096.
  • Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. 2000. Statins and the risk of dementia. Lancet 356: 16271631.
  • Kakio A, Nishimoto SI, Yanagisawa K, Kozutsumi Y, Matsuzaki K. 2001. Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein, an endogenous seed for Alzheimer amyloid. J Biol Chem 276: 2498524990.
  • Kivipelto M, Helkala EL, Hanninen T, Laakso MP, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A. 2001. Midlife vascular risk factors and late-life mild cognitive impairment: a population-based study. Neurology 56: 16831689.
  • Kojro E, Gimpl G, Lammich S, Marz W, Fahrenholz F. 2001. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10. Proc Natl Acad Sci USA 98: 58155820.
  • Koudinov AR, Koudinova NV. 2001. Essential role for cholesterol in synaptic plasticity and neuronal degeneration. FASEB J 15: 18581860.
  • Kuo YM, Emmerling MR, Bisgaier CL, Essenburg AD, Lampert HC, Drumm D, Roher AE. 1998. Elevated low-density lipoprotein in Alzheimer's disease correlates with brain Aβ 1-42 levels. Biochem Biophys Res Commun 252: 711715.
  • Launer LJ, White LR, Petrovitch H, Ross GW, Curb JD. 2001. Cholesterol and neuropathologic markers of AD: a population-based autopsy study. Neurology 57: 14471452.
  • Lesser G, Kandiah K, Libow LS, Likourezos A, Breuer B, Marin D, Mohs R, Haroutunian V, Neufeld R. 2001. Elevated serum total and LDL cholesterol in very old patients with Alzheimer's disease. Dement Geriatr Cogn Disord 12: 138145.
  • Liu Y, Peterson DA, Schubert D. 1998. Amyloid b peptide alters intracellular vesicle trafficking and cholesterol homeostasis. Proc Natl Acad Sci USA 95: 1326613271.
  • Mauch DH, Nagler K, Schumacher S, Goritz C, Muller EC, Otto A, Pfrieger FW. 2001. CNS synaptogenesis promoted by glia-derived cholesterol. Science 294: 13541357.
  • Michikawa M, Yanagisawa K. 1998. Apolipoprotein ϵ4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. J Neurosci Res 54: 5867.
  • Michikawa M, Fan QW, Isobe I, Yanagisawa K. 2000. Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture. J Neurochem 74: 10081016.
  • Michikawa M, Gong JS, Fan QW, Sawamura N, Yanagisawa K. 2001. A novel action of Alzheimer's amyloid β-protein (Aβ): oligomeric Aβ promotes lipid release. J Neurosci 21: 72267235.
  • Mizuno T, Nakata M, Naiki H, Michikawa M, Wang R, Haass C, Yanagisawa K. 1999. Cholesterol-dependent generation of a seeding amyloid β-protein in cell culture. J Biol Chem 274: 1511015114.
  • Mori T, Paris D, Town T, Rojiani AM, Sparks DL, Delledonne A, Crawford F, Abdullah LI, Humphrey JA, Dickson DW, Mullan MJ. 2001. Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice. J Neuropathol Exp Neurol 60: 778785.
  • Notkola IL, Sulkava R, Pekkanen J, Erkinjuntti T, Ehnholm C, Kivinen P, Tuomilehto J, Nissinen A. 1998. Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease. Neuroepidemiology 17: 1420.
  • Poirier J, Davington J, Bouthillier D, Kogan S, Bertrand P, Gauthier S. 1993. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 342: 697699.
  • Popplewell PY, Azhar S. 1987. Effects of aging on cholesterol content and cholesterol-metabolizing enzymes in the rat adrenal gland. Endocrinology 121: 6473.
  • Puglielli L, Konopka G, Pack-Chung E, Ingano LA, Berezovska O, Hyman BT, Chang TY, Tanzi RE, Kovacs DM. 2001. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide. Nat Cell Biol 3: 905912.
  • Racchi M, Baetta R, Salvietti N, Ianna P, Franceschini G, Paoletti R, Fumagalli R, Govoni S, Trabucchi M, Soma M. 1997. Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content. Biochem J 322: 893898.
  • Refolo LM, Malester B, LaFrancois J, Bryant-Thomas T, Wang R, Tint GS, Sambamurti K, Duff K, Pappolla MA. 2000. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis 7: 321331.
  • Saunders AM, Strittmatter WJ, Schmechel D, St. George-Hyslop PH, Pericak Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-Maclachlan DR, Growden J, Alberts MJ, Hulette C, Crain B, Goldgaber D, Roses AD. 1993. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43: 14671472.
  • Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Frosch MP, Ding K, Ito M, Kim TW, Tanzi RE, Oyama F, Tabira T, Ando S, Ihara Y. 2000. Mutant presenilin 2 transgenic mice. A large increase in the levels of Aβ 42 is presumably associated with the low density membrane domain that contains decreased levels of blycerophospholipids and sphingomyelin. J Biol Chem 275: 2790127908.
  • Sawamura N, Gong JS, Garver WS, Heidenreich RA, Ninomiya H, Ohno K, Yanagisawa K, Michikawa M. 2001. Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice. J Biol Chem 276: 1031410319.
  • Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K. 1998. Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 95: 64606464.
  • Sparks DL, Scheff SW, Hunsaker JC, 3rd, Liu H, Landers T, Gross DR. 1994. Induction of Alzheimer-like β-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp Neurol 126: 8894.
  • Stahlberg D, Angelin B, Einarsson K. 1991. Age-related changes in the metabolism of cholesterol in rat liver microsomes. Lipids 26: 349352.
  • Strittmatter WJ, Weisgraber KH, Huang DY, Dong L-M, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD 1993. Binding of human apolipoprotein E to synthetic amyloid β-peptide: isoform-specific effects and implications for late-onest Alzheimer disease. Proc Natl Acad Sci USA 90: 80988102.
  • Suzuki K, Parker CC, Pentchev PG, Katz D, Ghetti B, D'Agostino AN, Carstea ED. 1995. Neurofibrillary tangles in Niemann-Pick disease type C. Acta Neuropathol 89: 227238.
  • Vance JE, Pan D, Campenot RB, Bussiere M, Vance DE. 1994. Evidence that the major membrane lipids, except cholesterol, are made in axons of cultured rat sympathetic neurons. J Neurochem 62: 329337.
  • Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G. 2000. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol 57: 14391443.
  • Wood WG, Schroeder F, Avdulov NA, Chochina SV, Igbavboa U. 1999. Recent advances in brain cholesterol dynamics: transport, domains, and Alzheimer's disease. Lipids 34: 225234.
  • Yamazaki T, Chang TY, Haass C, Ihara Y. 2001. Accumulation and aggregation of amyloid β-protein in late endosomes of Niemann-pick type C cells. J Biol Chem 276: 44544460.
  • Yanagisawa K, Ihara Y. 1998. GM1 ganglioside-bound amyloid β-protein in Alzheimer's disease brain. Neurobiol Aging 19: S6567.
  • Yanagisawa K, Odaka A, Suzuki N, Ihara Y. 1995. GM1 ganglioside-bound amyloid β-protein (Aβ): a possible form of preamyloid in Alzheimer's disease. Nat Med 1: 10621066.
  • Yip CM, Elton EA, Darabie AA, Morrison MR, McLaurin J. 2001. Cholesterol, a modulator of membrane-associated Aβ-fibrillogenesis and neurotoxicity. J Mol Biol 311: 723734.