Is the soluble KDI domain of γ1 laminin a regeneration factor for the mammalian central nervous system?
Article first published online: 8 JUL 2003
Copyright © 2003 Wiley-Liss, Inc.
Journal of Neuroscience Research
Volume 73, Issue 5, pages 637–643, 1 September 2003
How to Cite
Liebkind, R., Laatikainen, T. and Liesi, P. (2003), Is the soluble KDI domain of γ1 laminin a regeneration factor for the mammalian central nervous system?. J. Neurosci. Res., 73: 637–643. doi: 10.1002/jnr.10692
- Issue published online: 14 AUG 2003
- Article first published online: 8 JUL 2003
- Manuscript Accepted: 2 MAY 2003
- Manuscript Revised: 30 APR 2003
- Manuscript Received: 31 MAR 2003
- University of Helsinki. Grant Number: 715321
- Adult CNS;
- KDI domain;
- γ1 laminin;
- regeneration factors
Regeneration of adult mammalian CNS is poor as a result of environmental factors that prevent axon growth. The major factors hampering regeneration of central axons include proteins released from the damaged myelin sheets of the injured neuronal pathways and formation of the glial scar. By using an experimental model of human CNS injury, we show that survival and neurite outgrowth of human central neurons are significantly enhanced by the soluble KDI domain of γ1 laminin. Our results indicate that the KDI domain appears to neutralize both glia-derived inhibitory signals and inhibitory molecules released from the myelin of the adult human spinal cord. We propose that the KDI domain may enhance regeneration of injuries in the adult mammalian CNS. © 2003 Wiley-Liss, Inc.