Microarray analysis of postmortem temporal cortex from patients with schizophrenia
Article first published online: 1 JUL 2004
Copyright © 2004 Wiley-Liss, Inc.
Journal of Neuroscience Research
Volume 77, Issue 6, pages 858–866, 15 September 2004
How to Cite
Aston, C., Jiang, L. and Sokolov, B. P. (2004), Microarray analysis of postmortem temporal cortex from patients with schizophrenia. J. Neurosci. Res., 77: 858–866. doi: 10.1002/jnr.20208
- Issue published online: 20 AUG 2004
- Article first published online: 1 JUL 2004
- Manuscript Revised: 13 MAY 2004
- Manuscript Accepted: 13 MAY 2004
- Manuscript Received: 22 MAR 2004
- circadian rhythms
To examine molecular mechanisms associated with schizophrenia this study measured expression of approximately 12,000 genes in the middle temporal gyrus from 12 subjects with schizophrenia and 14 matched normal controls. Among the most consistent changes in genes with robust expression were significant decreases in the expression of myelination-related genes MAG, PLLP (TM4SF11), PLP1, ERBB3 in subjects with schizophrenia. There was also altered expression of genes regulating neurodevelopment (TRAF4, Neurod1, histone deacetylase 3), a circadian pacemaker (PER1), and several other genes involved in regulation of chromatin function and signaling mechanisms. These findings support the hypothesis that schizophrenia is associated with abnormalities in oligodendroglia and provide initial evidence suggesting a role for epigenetic mechanisms and altered circadian rhythms in this disorder. © 2004 Wiley-Liss, Inc.