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Cytoplasmic domain of the β-amyloid protein precursor of Alzheimer's disease: Function, regulation of proteolysis, and implications for drug development

Authors

  • Megan L. Kerr,

    1. Laboratory of Molecular Neurobiology, Department of Biochemistry and Molecular Biology, and Monash University Centre for Brain and Behaviour, Monash University, Victoria, Australia
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  • David H. Small

    Corresponding author
    1. Laboratory of Molecular Neurobiology, Department of Biochemistry and Molecular Biology, and Monash University Centre for Brain and Behaviour, Monash University, Victoria, Australia
    • Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
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Abstract

The β-amyloid protein precursor (APP) has been extensively studied for its role in amyloid production and the pathogenesis of Alzheimer's disease (AD). However, little is known about the normal function of APP and its biological interactions. In this Mini-Review, the role of the cytoplasmic domain of APP in APP trafficking and proteolysis is described. These studies suggest that proteins that bind to the cytoplasmic domain may be important targets for drug development in AD. © 2005 Wiley-Liss, Inc.

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