Role of TPH-2 in brain function: News from behavioral and pharmacologic studies
Article first published online: 10 MAY 2007
Copyright © 2007 Wiley-Liss, Inc.
Journal of Neuroscience Research
Volume 85, Issue 14, pages 3030–3035, 1 November 2007
How to Cite
Invernizzi, R. W. (2007), Role of TPH-2 in brain function: News from behavioral and pharmacologic studies. J. Neurosci. Res., 85: 3030–3035. doi: 10.1002/jnr.21330
- Issue published online: 10 OCT 2007
- Article first published online: 10 MAY 2007
- Manuscript Accepted: 20 FEB 2007
- Manuscript Revised: 17 FEB 2007
- Manuscript Received: 29 NOV 2006
- tryptophan hydroxylase-2;
- mouse strains
The recent discovery of TPH-2, a new isoform of tryptophan hydroxylase, the enzyme that catalyses the transformation of tryptophan into 5-hydroxytryptophan and the rate-limiting step in brain serotonin (5-HT) biosynthesis, has boosted new interest in the many functions of 5-HT in the brain and non-nervous tissues. Recent studies on TPH-2 are reviewed with particular attention to the role of this enzyme in behavior and in response to drugs as assessed by comparing strains of mice carrying a functional polymorphism of TPH-2. Most studies concur to indicate that 5-HT synthesis through TPH-2 influence nervous tissues whereas TPH-1 is responsible for the synthesis and action of 5-HT in peripheral organs. Partial impairment of brain 5-HT synthesis caused by polymorphism of the gene encoding TPH-2 causes reduced release of the neurotransmitter, increased aggressiveness, and alters the response to drugs inhibiting the reuptake of 5-HT. Strain comparison might be a useful strategy to investigate the genotype-dependent alterations of TPH-2. © 2007 Wiley-Liss, Inc.