Nonmotor symptoms in Parkinson's disease: Investigating early-phase onset of behavioral dysfunction in the 6-hydroxydopamine-lesioned rat model
Article first published online: 11 MAR 2008
Copyright © 2008 Wiley-Liss, Inc.
Journal of Neuroscience Research
Volume 86, Issue 9, pages 2050–2061, July 2008
How to Cite
Branchi, I., D'Andrea, I., Armida, M., Cassano, T., Pèzzola, A., Potenza, R. L., Morgese, M. G., Popoli, P. and Alleva, E. (2008), Nonmotor symptoms in Parkinson's disease: Investigating early-phase onset of behavioral dysfunction in the 6-hydroxydopamine-lesioned rat model. J. Neurosci. Res., 86: 2050–2061. doi: 10.1002/jnr.21642
- Issue published online: 16 JUN 2008
- Article first published online: 11 MAR 2008
- Manuscript Accepted: 7 DEC 2007
- Manuscript Revised: 30 NOV 2007
- Manuscript Received: 10 OCT 2007
- Italian Ministry of Health
- NIH-ISS. Grant Number: Rif. 0F14
To investigate the psychiatric symptoms accompanying the early phases of Parkinson's disease (PD), we injected adult rats with 10.5 μg 6-hydroxydopamine (6-OHDA) bilaterally into the dorsal striatum. The resulting neurodegeneration led, 12 weeks after injection, to a mild (36%) reduction of striatal dopamine. We tested the behavioral response of sham and 6-OHDA-lesioned animals at different time points after injection to evaluate the onset and progression of behavioral abnormalities. The results showed that such a mild reduction of dopamine levels was associated with a decrease in anxiety-like behavior, an increase in “depression”-like behavior, and a marked change in social behavior. Learning and memory abilities were not affected. Overall, the PD rat model used here displays behavioral alterations having face validity with psychiatric symptoms of the pathology and thus appears to be a valuable tool for investigating the neural bases of the early phases of PD. © 2008 Wiley-Liss, Inc.