Minimum information about animal experiments: supplier is also important
Article first published online: 16 SEP 2008
Copyright © 2008 Wiley-Liss, Inc.
Journal of Neuroscience Research
Volume 87, Issue 2, pages 403–407, 1 February 2009
How to Cite
Lonjon, N., Prieto, M., Haton, H., Brøchner, C. B., Bauchet, L., Costalat, V., Privat, A., Gaviria, M. and Perrin, F. E. (2009), Minimum information about animal experiments: supplier is also important. J. Neurosci. Res., 87: 403–407. doi: 10.1002/jnr.21871
- Issue published online: 13 JAN 2009
- Article first published online: 16 SEP 2008
- Manuscript Accepted: 11 JUL 2008
- Manuscript Received: 5 APR 2008
- European Union FP6 “rescue” strep
- Institut pour la Recherche sur la Moelle Epinière
- Société Française de Neurochirurgie
- Neuréva Inc.
- functional recovery;
- lesion extension;
- vertebral canal;
It has now been established that functional recovery after spinal cord injury (SCI) depends on several parameters, including animal strain. Here we demonstrate that rats from the same strain (Wistar) but from two independent commercial suppliers present different motor, sensory, and autonomic outcomes after a standard model of SCI, the so-called compression model. Recovery is correlated with the extension of the lesion, and we show that the vertebral canal diameter varies between the two suppliers. To substantiate this point, we carried out another set of experiments, with the so-called contusion model, which requires bone ablation and thus whose extension is not related to vertebral canal diameter. We show that there is no difference between the two suppliers. The purpose of our communication is to alert researchers on how crucial it is to control experimental parameters as closely as possible and to establish a standard for animal experiment in order to avoid unexpected biases. © 2008 Wiley-Liss, Inc.