Early auditory experience-induced composition/ratio changes of N-methyl-D-aspartate receptor subunit expression and effects of D-2-amino-5-phosphonovaleric acid chronic blockade in rat auditory cortex

Authors

  • Yilei Cui,

    1. School of Life Science, Institute of Cognitive Neuroscience and Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, East China Normal University, Shanghai, China
    Current affiliation:
    1. Kresge Hearing Research Institute, Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan
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  • Jiping Zhang,

    1. School of Life Science, Institute of Cognitive Neuroscience and Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, East China Normal University, Shanghai, China
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  • Rui Cai,

    1. School of Life Science, Institute of Cognitive Neuroscience and Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, East China Normal University, Shanghai, China
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  • Xinde Sun

    Corresponding author
    1. School of Life Science, Institute of Cognitive Neuroscience and Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, East China Normal University, Shanghai, China
    • School of Life Science, KHRI, East China Normal University, Shanghai 200062, China
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Abstract

Auditory function can be affected by many factors, including environment and experience. In this study, we investigated whether early auditory experience mediates the regulation of the composition/ratio changes of the N-methyl-D-aspartic acid (NMDA) receptor subunits during development of the rat auditory cortex. We found that early sound exposure can increase expression of the NMDA receptor subunits and increase the composition/ratios of NMDA receptor subunits during the postnatal critical period. D-2-amino-5-phosphonovaleric acid (D-APV) could block and reverse the auditory experience-mediated changes, and there were marked reductions in expression levels and the composition/ratios of NMDA receptor subunits. These results indicate that the experience-dependent plasticity of the auditory cortex in the critical period during postnatal development has a marked influence on NMDA receptor expression in the rat and that changes in NMDA receptor subunit composition/ratios might mediate the early auditory experience-dependent plasticity crucial to auditory function. © 2008 Wiley-Liss, Inc.

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