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Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: A review

  1. Casey M. O'Dell1,
  2. Arabinda Das1,
  3. Gerald Wallace IV1,
  4. Swapan K. Ray2,
  5. Naren L. Banik1,*

Article first published online: 8 FEB 2012

DOI: 10.1002/jnr.22829

Issue

Journal of Neuroscience Research

Journal of Neuroscience Research

Volume 90, Issue 5, pages 913–924, May 2012

Additional Information

How to Cite

O'Dell, C. M., Das, A., Wallace, G., Ray, S. K. and Banik, N. L. (2012), Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: A review. J. Neurosci. Res., 90: 913–924. doi: 10.1002/jnr.22829

Author Information

  1. 1

    Division of Neurology, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina

  2. 2

    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina

*PhD, Division of Neurology, Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425

Publication History

  1. Issue published online: 7 MAR 2012
  2. Article first published online: 8 FEB 2012
  3. Manuscript Accepted: 9 OCT 2011
  4. Manuscript Revised: 5 OCT 2011
  5. Manuscript Received: 11 AUG 2011

Funded by

  • National Institute of Neurological Disorders and Stroke. Grant Numbers: NS-31622, NS-38146, NS-41088

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Keywords:

  • temporal lobe epilepsy;
  • calpain;
  • epileptogenesis;
  • cytokines

Abstract

Despite years of research, epilepsy remains a poorly understood disorder. In the past several years, work has been conducted on a variety of projects with the goal of better understanding the pathogenesis and progression of mesial temporal lobe epilepsy (MTLE), in particular, and how to exploit those properties to generate innovative therapies for treatment of refractory epilepsies. This review seeks to give an overview of common morphological and biochemical changes associated with epilepsy and proposed treatments to address those changes. Furthering the understanding of ictogenesis and epileptogenesis remains an important goal for scientists seeking to find more effective treatments for MTLE. © 2012 Wiley Periodicals, Inc.

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