Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells

Authors

  • M. B. Graeber,

    1. Department of Neuromorphology, Max-Planck-Institute for Psychiatry, Martinsried, Federal Republic of Germany
    Search for more papers by this author
  • W. J. Streit,

    1. Department of Neuromorphology, Max-Planck-Institute for Psychiatry, Martinsried, Federal Republic of Germany
    Search for more papers by this author
  • Prof. G. W. Kreutzberg

    Corresponding author
    1. Department of Neuromorphology, Max-Planck-Institute for Psychiatry, Martinsried, Federal Republic of Germany
    • Max Planck Institute for Psychiatry, Department of Neuromorphology, Am Klopferspitz 18a, D-8033 Martinsried, Federal Republic of Germany
    Search for more papers by this author

Abstract

Axotomy of the rat facial nerve leads to mitotic divisions of microglial cells without developing into phagocytes. In order to study the functional characteristics of those activated, i.e., proliferating but nonphagocytic, microglia we investigated the expression of monocyte/macrophage antigens by these cells. Our results show that activated microglia lack monocyte/macrophage antigens recognized by the monoclonal antibodies Ox-41, ED1, ED2, and Ki-M2R but express high levels of CR3 complement receptors in situ.

Ancillary