The role of microtubule-associated protein 2 (MAP-2) in neuronal growth, plasticity, and degeneration
Article first published online: 11 OCT 2004
Copyright © 1992 Wiley-Liss, Inc.
Journal of Neuroscience Research
Volume 33, Issue 4, pages 505–512, December 1992
How to Cite
Johnson, G. V. W. and Jope, R. S. (1992), The role of microtubule-associated protein 2 (MAP-2) in neuronal growth, plasticity, and degeneration. J. Neurosci. Res., 33: 505–512. doi: 10.1002/jnr.490330402
- Issue published online: 11 OCT 2004
- Article first published online: 11 OCT 2004
- Manuscript Accepted: 11 AUG 1992
- Manuscript Revised: 10 AUG 1992
- Manuscript Received: 8 JUN 1992
Microtubule associated protein 2 (MAP-2) historically has been perceived primarily as a static, structural protein, necessary along with other cytoskeletal proteins to maintain neuroarchitecture but somewhat removed from the “mainstream” of neuronal response mechanisms. Quite to the contrary, MAP-2 is exquisitely sensitive to many inputs and recent investigations have revealed dynamic functions for MAP-2 in the growth, differentiation, and plasticity of neurons, with key roles in neuronal responses to growth factors, neurotransmitters, synaptic activity, and neurotoxins. These discoveries indicate that modification and rearrangement of MAP-2 is an early obligatory step in many processes which modify neuronal function. © 1992 Wiley-Liss, Inc.