Role for the stem cell factor/KIT complex in schwann cell neoplasia and mast cell proliferation associated with neurofibromatosis
Version of Record online: 11 OCT 2004
Copyright © 1994 Wiley-Liss, Inc.
Journal of Neuroscience Research
Volume 37, Issue 3, pages 415–432, 15 February 1994
How to Cite
Ryan, J. J., Klein, K. A., Neuberger, T. J., Leftwich, J. A., Westin, E. H., Kauma, S., Fletcher, J. A., DeVries, G. H. and Huff, T. F. (1994), Role for the stem cell factor/KIT complex in schwann cell neoplasia and mast cell proliferation associated with neurofibromatosis. J. Neurosci. Res., 37: 415–432. doi: 10.1002/jnr.490370314
- Issue online: 11 OCT 2004
- Version of Record online: 11 OCT 2004
- Manuscript Accepted: 30 NOV 1993
- Manuscript Revised: 22 NOV 1993
- Manuscript Received: 28 JUL 1993
- Schwann cell;
- mast cell;
- stem cell factor;
Schwann cells are the primary cell type in the disfiguring lesions associated with neurofibromatosis type 1 (NF-1). These lesions also contain abnormally high numbers of mast cells, a cell type which develops in response to stem cell factor. We report here that neonatal and adult rat and human Schwann cells, as well as a transfected rat Schwann cell line and a human Schwannoma line derived from an NF-1 patient, all produced stem cell factor mRNA and protein. In coculture experiments, surface expression of stem cell factor by neonatal rat Schwann cells was profoundly downregulated by contact with dorsal root ganglion neurites. The receptor for stem cell factor, KIT, was not expressed in normal Schwann cells but was expressed in the human Schwannoma line, suggesting that aberrant KIT expression may form an autocrine loop in certain Schwann cell neoplasias. © 1994 Wiley-Liss, Inc.