Expression and distribution of functional intergrins in rat CNS glia
Article first published online: 11 OCT 2004
Copyright © 1994 Wiley-Liss, Inc.
Journal of Neuroscience Research
Volume 39, Issue 4, pages 436–447, 1 November 1994
How to Cite
Tawil, N. J., Wilson, P. and Carbonetto, S. (1994), Expression and distribution of functional intergrins in rat CNS glia. J. Neurosci. Res., 39: 436–447. doi: 10.1002/jnr.490390411
- Issue published online: 11 OCT 2004
- Article first published online: 11 OCT 2004
- Manuscript Accepted: 30 MAR 1994
- Manuscript Revised: 29 MAR 1994
- Manuscript Received: 22 NOV 1993
- extracellular matrix;
In previous studies, we have reported on the expression of β1 intergrins in type 1 astrocytes and their function in cell-substratum attachment (Tawil et al., J Cell Biol 120:261–271, 1993). Here we extend those findings by providing evidence that type 1 astrocytes express integrins of the β3 and possibly β4 subclasses and that the former (αvβ3) functions in attachment by recognizing the peptide, Arg-Gly-Asp, in vitronectin. In addition, we have examined immunocyto-chemically the expression of β1 integrins on type 2 astrocytes and oligodendrocytes. The pattern of expression of integrins on these two cell types is distinct from type 1 astrocytes; most notably type 1 astrocytes but not oligodendrocytes or type 2 astrocytes express α1β1 heterodimers. Since type 2 astrocytes and oligodendrocytes originate from a common precursor (0-2A), the α1β1 heterodimer may be a functional marker which distinguishes O-2A-derived cells from those of the type 1 astrocyte lineage. © 1994 Wiley-Liss, Inc.