Cellular roles of neuronal calcium sensor-1 and calcium/calmodulin-dependent kinases in fungi



The neuronal calcium sensor-1 (NCS-1) possesses a consensus signal for N-terminal myristoylation and four EF-hand Ca2+-binding sites, and mediates the effects of cytosolic Ca2+. Minute changes in free intracellular Ca2+ are quickly transformed into changes in the activity of several kinases including calcium/calmodulin-dependent protein kinases (Ca2+/CaMKs) that are involved in regulating many eukaryotic cell functions. However, our current knowledge of NCS-1 and Ca2+/CaMKs comes mostly from studies of the mammalian enzymes. Thus far very few fungal homologues of NCS-1 and Ca2+/CaMKs have been characterized and little is known about their cellular roles. In this minireview, we describe the known sequences, interactions with target proteins and cellular roles of NCS-1 and Ca2+/CaMKs in fungi. (© 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)