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Research Paper
The expression of LytM is down-regulated by RNAIII in Staphylococcus aureus
Article first published online: 14 MAY 2012
DOI: 10.1002/jobm.201100426
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Chunhua, M., Yu, L., Yaping, G., Jie, D., Qiang, L., Xiaorong, T. and Guang, Y. (2012), The expression of LytM is down-regulated by RNAIII in Staphylococcus aureus. J. Basic Microbiol., 52: 636–641. doi: 10.1002/jobm.201100426
Publication History
- Issue published online: 12 DEC 2012
- Article first published online: 14 MAY 2012
- Manuscript Accepted: 12 NOV 2011
- Manuscript Received: 25 AUG 2011
Funded by
- Chinese National Key Program on Basic Research. Grant Number: 2005CB724600
- National Natural Science Foundation of China. Grant Numbers: 30700007, 30870093, 30900019, 31000040
- National High-Tech Research and Development Program. Grant Numbers: 2006AA02Z132, 2006AA02Z323
- Abstract
- References
- Cited By
Keywords:
- S. aureus;
- LytM;
- RNA III
Abstract
LytM is one kind of autolysin expressed in Staphylococcus aureus. It can hydrolyze peptide bond of pentaglycine, which is the component of cell wall. Until now, the regulation on the expression of LytM is still unclear. Here, we found that the level of LytM in the RNAIII mutant was increased. RNAIII is an important small regulatory RNA in S. aureus. Our further investigation revealed that RNAIII can interact with the 5′UTR of lytM mRNA and block the ribosome binding sites [RBS]. So our results identified that LytM was the new target of RNAIII. (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)