This publication was, in part, the basis for Dr. Caplan's receiving the Elizabeth Winston Lanier Award given by the American Academy of Orthopaedic Surgeons as part of their 1990 Kappa Delta Awards.
Mesenchymal stem cells†
Article first published online: 18 FEB 2005
Copyright © 1991 Orthopaedic Research Society
Journal of Orthopaedic Research
Volume 9, Issue 5, pages 641–650, September 1991
How to Cite
Caplan, A. I. (1991), Mesenchymal stem cells. J. Orthop. Res., 9: 641–650. doi: 10.1002/jor.1100090504
- Issue published online: 18 FEB 2005
- Article first published online: 18 FEB 2005
- Manuscript Accepted: 17 JAN 1991
- Manuscript Received: 17 SEP 1990
- Mesenchymal stem cells;
- Self-cell therapy;
- Skeletal tissue;
Bone and cartilage formation in the embryo and repair and turnover in the adult involve the progeny of a small number of cells called mesenchymal stem cells. These cells divide, and their progeny become committed to a specific and distinctive phenotypic pathway, a lineage with discrete steps and, finally, end-stage cells involved with fabrication of a unique tissue type, e.g., cartilage or bone. Local cuing (extrinsic factors) and the genomic potential (intrinsic factors) interact at each lineage step to control the rate and characteristic phenotype of the cells in the emerging tissue. The study of these mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self-cell repair. The isolation, mitotic expansion, and site-directed delivery of autologous stem cells can govern the rapid and specific repair of skeletal tissues.