• 1
    Adams ME, Matyas JR, Huang D, Dourado GS: Expression of proteoglycans and collagen in the hypertrophic phase of experimental osteoarthritis. J Rheumatol 43 (Suppl): 9497, 1995
  • 2
    Altman RD, Tenenbaum J, Latta L, Riskin W, Blanco LN, Howell DS: Biomechanical and biochemical properties of dog cartilage in experimentally induced osteoarthritis. Ann Rheum Dis 43: 8390, 1984
  • 3
    Armstrong CG, Mow VC: Variations in the intrinsic mechanical properties of human articular cartilage with age, degeneration, and water content. J Bone Joint Surg [Am] 64: 8894, 1982
  • 4
    Arokoski JP, Hyttinen MM, Lapvetelainen T, Takacs P, Kosztaczky B, Modis L, Kovanen V, Helminen H: Decreased birefringence of the superficial zone collagen network in the canine knee (stifle) articular cartilage after long distance running training, detected by quantitative polarised light microscopy. Ann Rheum Dis 55: 253264, 1996
  • 5
    Athanasiou KA, Rosenwasser MP, Buckwalter JA, Malinin TI, Mow VC: Interspecies comparisons of in situ intrinsic me-chanical properties of distal femoral cartilage. J Orthop Res 9: 330340, 1991
  • 6
    Bonassar LJ, Frank EH, Murray JC, Paguio CG, Moore VL, Lark MW, Sandy JD, Wu JJ, Eyre DR, Grodzinsky AJ: Changes in cartilage composition and physical properties due to stromelysin degradation. Arthritis Rheum 38: 173183, 1995
  • 7
    Brandt KD: Compensation and decompensation of articular cartilage in osteoarthritis. Agents Actions 40: 232234, 1993
  • 8
    Breinan H, Minas T, Hsu H, Nehrer S, Sledge C, Spector M: Effect of cultured autologous chondrocytes on repair of chondral defects in a canine model. J Bone Joint Surg [Am] 79: 14391451, 1997
  • 9
    Breinan HA, Martin SD, Hsu H-P, Spector M: Healing of canine articular cartilage defects treated with microfracture, a type-II collagen matrix, or cultured autologous chondrocytes. J Orthop Res 18: 781789, 2000
  • 10
    Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L: Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331: 889895, 1994
  • 11
    Buckwalter JA, Mankin HJ: Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. AAOS Instruct Course Lect 47: 487504, 1998
  • 12
    Carney SL, Billingham ME, Muir H, Sandy JD: Demonstration of increased proteoglycan turnover in cartilage explants from dogs with experimental osteoarthritis. J Orthop Res 2: 201206, 1984
  • 13
    Chu CR, Dounchis JS, Yoshioka M, Sah RL, Coutts RD, Amiel D: Osteochondral repair using perichondrial cells: a 1-year study in rabbits. Clin Orthop 340: 220229, 1997
  • 14
    Coutts RD, Yoshioka M, Amiel D, Hacker SA, Harwood FL, Monosov A: Cartilage repair using a porous polylactic acid matrix with allogeneic perichondrial cells. Trans Orthop Res Soc 19: 240, 1994
  • 15
    Frenkel SR, Toolan B, Menche D, Pitman MI, Pachence JM: Chondrocyte transplantation using a collagen bilayer matrix for cartilage repair. J Bone Joint Surg [Br] 79: 831836, 1997
  • 16
    Ghadially FN, Thomas I, Oryschak AF, Lalonde JM: Longterm results of superficial defects in articular cartilage: a scanning electron microscope study. J Pathol 121: 213217, 1977
  • 17
    Guilak F, Ratcliffe A, Lane N, Rosenwasser MP, Mow VC: Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis. J Orthop Res 12: 474484, 1994
  • 18
    Hale JE, Rudert MJ, Brown TD: Indentation assessment of biphasic mechanical property deficits in size-dependent osteochondral defect repair. J Biomech 26: 13191325, 1993
  • 19
    Havdrup T, Telhag H: Scattered mitosis in adult joint cartilage after partial chondrectomy: a histological, autoradiographical and biochemical study in rabbits. Acta Orthop Scand 49: 424429, 1978
  • 20
    Havdrup T, Telhag H: Mitosis of chondrocytes in normal adult joint cartilage. Clin Orthop 153: 248252, 1980
  • 21
    Hayes WC, Keer LM, Herrmann G, Mockros LF: A mathematical analysis for indentation tests of articular cartilage. J Biomech 5: 541551, 1972
  • 22
    Hoch DH, Grodzinsky AJ, Koob TJ, Albert ML, Eyre DR: Early changes in material properties of rabbit articular cartilage after meniscectomy. J Orthop Res 1: 412, 1983
  • 23
    Jurvelin J, Kiviranta I, Arokoski J, Tammi M, Helminen HJ: Indentation study of the biomechanical properties of articular cartilage in the canine knee. Eng Med 16: 1522, 1987
  • 24
    Kawamura S, Wakitani S, Kimura T, Maeda A, Caplan AI, Shino K, Ochi T: Articular cartilage repair: rabbit experiments with a collagen gel-biomatrix and chondrocytes cultured in it. Act Orthop Scand 69: 5662, 1998
  • 25
    Lin BY, Sebern EL, Frank EH, Dube N, Grodzinsky AJ, Gross GJ, Hookfin EB, Deutsch AG, Prenger MC, Meyer JM: Changes in physical and biochemical properties of cartilage in the guinea pig spontaneous OA model are consistent with hypertrophic remodeling. Trans Orthop Res Soc 23: 130, 1998
  • 26
    Mankin H: The reaction of articular cartilage to injury and osteoarthritis (second of two parts). N Engl J Med 291: 13351340, 1974
  • 27
    Mankin HJ, Dorfman H, Lippiello L, Zarins A: Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II: Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg [Am] 53: 523537, 1971
  • 28
    Mankin HJ: The response of articular cartilage to mechanical injury. J Bone Joint Surg [Am] 64: 460466, 1982
  • 29
    Messner K, Gillquist J: Synthetic implants for the repair of osteochondral defects of the medial femoral condyle: a biomechanical and histological evaluation in the rabbit knee. Biomaterials 14: 513521, 1993
  • 30
    Minas T, Nehrer S: Current concepts in the treatment of articular cartilage defects. Orthopedics 20: 525538, 1997
  • 31
    Nehrer S, Breinan HA, Ramappa A, Young G, Shortkroff S, Louie L, Sledge CB, Yannas IV, Spector M: Matrix collagen type and pore size influence behaviour of seeded canine chondrocytes. Biomaterials 18: 769776, 1997
  • 32
    Nehrer S, Breinan HA, Ramappa A, Hsu HP, Minas T, Shortkroff S, Sledge CB, Yannas IV, Spector M: Chondrocyteseeded collagen matrices implanted in a chondral defect in a canine model. Biomaterials 19: 23132328, 1998
  • 33
    Rahfoth B, Weisser J, Sternkopf F, Aigner T, von der Mark K, Brauer R: Transplantation of allograft chondrocytes embedded in agarose gel into cartilage defects of rabbits. Osteoarthritis Cartilage 6: 5065, 1998
  • 34
    Rich D, Johnson E, Zhou L, Grande D: The use of periosteal cell/polymer tissue constructs for the repair of articular cartilage defects. Trans Orthop Res Soc 19: 241, 1994
  • 35
    Sams AE, Minor RR, Wootton JA, Mohammed H, Nixon AJ: Local and remote matrix responses to chondrocyte-laden collagen scaffold implantation in extensive articular cartilage defects. Osteoarthritis Cartilage 3: 6170, 1995
  • 36
    Setton LA, Mow VC, Muller FJ, Pita JC, Howell DS: Mechanical properties of canine articular cartilage are significantly altered following transection of the anterior cruciate ligament. J Orthop Res 12: 451463, 1994
  • 37
    Speer KP, Callaghan JJ, Seaber AV, Tucker JA: The effects of exposure of articular cartilage to air: a histochemical and ultrastructural investigation. J Bone Joint Surg [Am] 72: 14421450, 1990
  • 38
    Too An BC, Frenkel SR, Pereira DS, Alexander H: Developn ent of a novel osteochondral graft for cartilage repair. J Biomed Mater Res 41: 244250, 1998
  • 39
    Wakitani S, Ono K, Goldberg VM, Caplan AI: Repair of large cart lage defects in weight-bearing and partial weight-bearing articular surfaces with allograft articular chondrocytes embedded in collagen gels. Trans Orthop Res Soc 19: 238, 1994