Research Article

Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models†

  1. Jun Li1,
  2. Wendy Anemaet1,
  3. Michael A. Diaz2,
  4. Samuel Buchanan1,
  5. Micky Tortorella3,
  6. Anne Marie Malfait1,2,
  7. Katalin Mikecz4,
  8. John D. Sandy1,
  9. Anna Plaas1,2,*

Article first published online: 26 OCT 2010

DOI: 10.1002/jor.21215

Issue

Journal of Orthopaedic Research

Journal of Orthopaedic Research

Volume 29, Issue 4, pages 516–522, April 2011

Additional Information

How to Cite

Li, J., Anemaet, W., Diaz, M. A., Buchanan, S., Tortorella, M., Malfait, A. M., Mikecz, K., Sandy, J. D. and Plaas, A. (2011), Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models. J. Orthop. Res., 29: 516–522. doi: 10.1002/jor.21215

Author Information

  1. 1

    Department of Biochemistry, Rush University Medical Center, Chicago, Illinois

  2. 2

    Department of Internal Medicine (Rheumatology), Rush University Medical Center, Chicago, Illinois

  3. 3

    Guangzhou Institute for Biomedicine and Health, Guangzhou, China

  4. 4

    Department of Immunology, Rush University Medical Center, Chicago, Illinois

*Department of Biochemistry, Rush University Medical Center, Chicago, Illinois. T: 312-942-7194; F: 312-942-3053.

  1. †

    Jun Li and Wendy Anemaet contributed equally to this study.

Publication History

  1. Issue published online: 17 FEB 2011
  2. Article first published online: 26 OCT 2010
  3. Manuscript Accepted: 24 JUN 2010
  4. Manuscript Received: 17 APR 2010

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