Periprosthetic osteolysis: Characterizing the innate immune response to titanium wear-particles

Authors

  • Christine A. St. Pierre,

  • Melvin Chan,

  • Yoichiro Iwakura,

  • David C. Ayers,

  • Evelyn A. Kurt-Jones,

  • Robert W. Finberg

Errata

This article corrects:

  1. Periprosthetic osteolysis: Characterizing the innate immune response to titanium wear-particles Volume 28, Issue 11, 1418–1424, Article first published online: 22 April 2010

An error was introduced to Figure 5 in the print version of this article. The original online version had been correct. The PYD in the figure was changed to PYR. However, the expression PYD remained in the legend. The corrected figure is shown here. The Publisher regrets this error.

Figure 5.

Ti triggers inflammasome activation. Ti particle internalization triggers the release of Cathepsin B from lyso-somes, which together activate Nalp3. Activated NalpS recruits-ASC through PYD domain interactions. This complex triggers cleavage and recruitment of activated Caspase-1 through CARD domain interactions. This inflammasome complex then cleaves pro-IL-1β into its active, secreted form IL-1β, which can trigger downstream IL-1-associated signaling, including neutrophil recruitment, through activation of the IL-1R. This acute inflammatory response can he inhibited with JGL-lRa treatment.

The Publisher regrets this error.

The article to which this Erratum refers was published in the November 2010 issue, pages 1418–1424.

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