Efficacy of antibacterial bioactive glass S53P4 against S. aureus biofilms grown on titanium discs in vitro
Article first published online: 25 SEP 2013
© 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Journal of Orthopaedic Research
Volume 32, Issue 1, pages 175–177, January 2014
How to Cite
Coraça-Huber, D. C., Fille, M., Hausdorfer, J., Putzer, D. and Nogler, M. (2014), Efficacy of antibacterial bioactive glass S53P4 against S. aureus biofilms grown on titanium discs in vitro. J. Orthop. Res., 32: 175–177. doi: 10.1002/jor.22463
- Issue published online: 19 NOV 2013
- Article first published online: 25 SEP 2013
- Manuscript Accepted: 16 JUL 2013
- Manuscript Received: 21 JUN 2013
- bioactive glass;
- bone substitute;
- Staphylococcus aureus;
- periprosthetic joint infections
We evaluated the effectiveness of different sizes of bioactive glass S53P4 against Staphylococcus aureus biofilms grown on metal discs in vitro. S. aureus biofilms were cultivated on titanium discs. BAG-S53P4 (0.5–0.8 mm and <45 µm) were placed in contact with the discs containing biofilms. Glass beads (0.5 mm) were used as a control. After each interval, the pH from each sample was measured. Colony forming units were counted for the biofilm recovery verification. In parallel, we tested the activity of bioactive glass against S. aureus planktonic cells. We found that BAG-S53P4 can suppress S. aureus biofilm formation on titanium discs in vitro. The suppression rate of biofilm cells by BAG-S53P4 <45 µm was significantly higher than by BAG-S53P4 0.5–0.8 mm. BAG-S53P4 has a clear growth-inhibitory effect on S. aureus biofilms. BAG-S53P4 <45 µm is more efficient against biofilm growth in vitro comparing with BAG-S53P4 0.5–0.8 mm. Bioactive glass S53P4 has potential to be used as bone substitute for the resolution of infection complications in joint replacement surgeries and treatment of chronic osteomyelitis. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:175–177, 2014.